Research output per year
Research output per year
Personal profile
Contact Details
email: [email protected]
tel: +44 (0) 121 204 4165
fax: +44 (0) 121 204 4187
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Research Interests
As an inflammatory cell biologist, my research over 20 years has focused on the innate immune system and its role in protection and tissue repair through the study of phagocyte clearance of dying (apoptotic) cells and microbial challenge. Research within my research group addresses membrane receptors/ligands and cell communication in this phagocytic clearance process. Current work aims to define the mechanisms by which apoptotic cells communicate via extracellular vesicles (EV). This BBSRC-funded work is revealing novel EV structure-function relationships that underpin tissue repair and regeneration capacity of EV from both apoptotic and viable cells, including mesenchymal stem cells. This research has introduced the concept that EV are an active extracellular metabolic compartment capable of modulating inflammation. The ultimate aim of my group’s research is to modify inflammation for therapeutic gain either through the inhibition of inflammation (e.g. in cardiovascular disease and regenerative medicine applications) or promoting inflammation (e.g. in tumours).
Teaching Activity
Undergraduate:
Year 2 (level 5) Immunology & microbiology
Year F (level 6) Immunology
Postgraduate:
Level 7 Immunology and Cell Biology
Employment
- 2018-present Head of Biosciences, Aston University
- 2017-present Professor in Inflammatory Cell Biology, Aston University
- 2015-2017 Reader in Inflammatory Cell Biology, Aston University
- 2012-2015 Senior Lecturer in Cell Biology, Aston University
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2005-2012 Lecturer in Cell Biology
Aston University -
2001-2005 Senior Research Fellow
MRC Centre for Inflammation Research
The University of Edinburgh, UK -
1997-2001 Research Fellow
School of Biomedical Sciences, Nottingham University, UK -
1995-1997 Research Fellow
Department of Immunology
The University of Birmingham, UK -
1995 Ph.D. Microbiology
School of Biological Sciences
The University of Birmingham, UK (Wellcome Prize studentship) -
1991 B.Sc. (HONS) First Class, Microbiology
Department of Cell & Structural Biology, The University of Manchester
Membership of Professional Bodies
- Fellow of the Royal Society of Biology
- Fellow of the Higher Education Academy
- Member - UKEV: UK Extracellular Vesicle Society
- Member - British Society for Immunology
- Member - International Society for Extracellular Vesicles
- Member - The Biochemical Society
- Member - The Society For Leukocyte Biology
- Member - European Cell Death Organization
Education/Academic qualification
PhD, Host cell responses to chlamydial infection, University of Birmingham
Award Date: 1 Jun 1995
BSc, Microbiology, University of Manchester
Award Date: 1 Jul 1991
External positions
Member -Dunhill Medical Trust Research Grants Committee
Chair BBSRC Committee A, UKRI-BBSRC
External Examiner, University of Edinburgh
External Examiner, York St John, York St John University
Keywords
- QR180 Immunology
- Intercellular Communication
- Extracellular Vesicles (EV)
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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JNK Activation Correlates with Cognitive Impairment and Alteration of the Post-Synaptic Element in the 5xFAD AD Mouse Model
Priori, E. C., Musi, C. A., Giani, A., Colnaghi, L., Milic, I., Devitt, A., Borsello, T. & Repici, M., 15 Mar 2023, In: Cells. 12, 6, 15 p., 904.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Development of a rapid in vitro pre-screen for distinguishing effective liposome-adjuvant delivery systems
Feather, L. A. J., Nadella, V., Kastner, E., Perrie, Y., Hilton, A. C. & Devitt, A., 20 Jul 2022, In: Scientific Reports. 12, 1, 12448.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Emerging roles for AQP in mammalian extracellular vesicles
Clarke-Bland, C. E., Bill, R. M. & Devitt, A., 1 Mar 2022, In: BBA -Biomembranes. 1864, 3, 183826.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Macrophages: the Good, the Bad, and the Gluttony
Ross, E., Devitt, A. & Johnson, J., 12 Aug 2021, In: Frontiers in Immunology. 12, 708186.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
Biophysical analysis of lipidic nanoparticles
Rozo, A. J., Cox, M. H., Devitt, A., Rothnie, A. J. & Goddard, A. D., 1 Aug 2020, In: Methods. 180, p. 45-55 11 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile
Datasets
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CD81 extracted in SMALP nanodiscs comprises two distinct protein populations within a lipid environment enriched with negatively charged headgroups
Ayub, H. (Creator), Clare, M. (Creator), Milic, I. (Creator), Chmel, N. P. (Creator), Böning, H. (Creator), Devitt, A. (Creator), Krey, T. (Creator), Bill, R. (Creator) & Rothnie, A. (Creator), Aston Data Explorer, 19 Dec 2019
DOI: 10.17036/researchdata.aston.ac.uk.00000454, https://www.sciencedirect.com/science/article/pii/S0005273620302625
Dataset
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Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients
Ademowo, S. (Creator), Dias, I. (Creator), Milic, I. (Creator), Devitt, A. (Creator), Moran, R. (Creator), Mulcahy, R. (Creator), Howard, A. (Creator), Nolan, J. (Creator) & Griffiths, H. (Creator), Aston Data Explorer, 16 Mar 2017
DOI: 10.17036/dd4fed57-df9e-439d-899e-59e242ec1a5f, https://www.sciencedirect.com/science/article/pii/S0891584917301326?via%3Dihub
Dataset
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Porphyromonas gingivalis gingipains cause defective macrophage migration towards apoptotic cells and inhibit phagocytosis of primary apoptotic neutrophils
Ajay Castro, S. (Creator), Collighan, R. (Creator), Lambert, P. (Creator), Dias, I. (Creator), Chauhan, P. (Creator), Clarke-Bland, C. (Creator), Milic, I. (Creator), Milward, M. (Creator), Cooper, P. R. (Creator) & Devitt, A. (Creator), Aston Data Explorer, 23 Feb 2017
DOI: 10.17036/researchdata.aston.ac.uk.00000202, https://www.nature.com/articles/cddis2016481
Dataset
Prizes
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Fellow of the Institute of Biomedical Science (FIBMS)
Devitt, A. (Recipient), 2014
Prize: Election to learned society
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Fellow of the Royal Society of Biology
Devitt, A. (Recipient), 2014
Prize: Election to learned society
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Fellow of the Higher Education Academy (FHEA)
Devitt, A. (Recipient), 2008
Prize: Election to learned society
Activities
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The Dunhill Medical Trust (External organisation)
Devitt, A. (Chair)
2017Activity: Membership types › Membership of committee
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Biotechnology and Biological Sciences Research Council (External organisation)
Devitt, A. (Chair)
May 2015 → …Activity: Membership types › Membership of council
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IZON Science research symposium 2014
Devitt, A. (Invited speaker)
Sept 2014Activity: Participating in or organising an event types › Participation in conference
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3rd internation meeting of the International Society for Extracellular Vesicles
Devitt, A. (Invited speaker)
May 2014Activity: Participating in or organising an event types › Participation in conference
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Macrophage (Journal)
Devitt, A. (Editorial board member)
2014 → …Activity: Peer-review and editorial work types › Editorial activity