Personal profile

Biography

Hine gained her PhD in Molecular Biology from UMIST in 1992 and her postdoctoral training at Harvard Medical School (PI: Prof Charles C. Richardson). She returned to the UK to take up a lectureship in Molecular Biology at Aston University in 1995. In 2003 she commenced her combined career in academia and innovation with a Medici Fellowship (commercialisation and entrepreneurial training), which was later followed by a secondment to the University's Business Partnership Unit as the School of Life and Health Sciences' Innovation Fellow. She was promoted to Senior Lecturer in 2006, Reader in 2013, Associate Dean in 2015 and Chair in 2018.  The mother of two children, she has worked part time (0.7/0.8 FTE) since 2003.

Research Interests

  • Protein Engineering
  • Research at the interface between molecular biology and the physical sciences
  • Development of enabling technologies for biomedicines
  • Protein-DNA interactions of Cys2His2 zinc fingers
  • Protein-DNA interactions of single Cys4 zinc fingers

Hine's research centres on combinatorial, synthetic biology and its application to protein-ligand interactions. She was named the BBSRC Commercial Innovator of the Year 2013; an award made for her successful transfer of her group’s inventions in protein engineering into UK-based Biotech company Isogenica Ltd.  ColibraTM is now being exploited by Isogenica in the production of their highly-diverse synthetic antibody libraries.

Resulting from numerous multi-disciplinary collaborations, she also has experience of developing novel screens and in exploiting protein-DNA interactions to achieve advances in biotech process engineering.  Her interdisciplinary work has generated several photonic biosensors, a generic technology to deliver and release proteins within mammalian cells and most recently, in an international FET-OPEN project is developing synthetic replacements for monoclonal reagent antibodies.

Research Projects/Collaborations

Awards

  • 2013 BBSRC Commercial Innovator of the Year
  • 2013 Aston Excellence Award for Outstanding Contribution to Innovation and/or Technological Improvement

Membership of Professional Bodies

  • Fellow of the Royal Society of Biology
  • Member of the Biochemical Society
  • Senior Fellow of the Higher Education Academy

Employment

  • 2018-date Professor of Protein Engineering, Aston University
  • 2015-date Associate Dean, Enterprise, Aston University
  • 2013-2018 Reader in Molecular Biology, Aston University
  • 2009-2012 Course Director, MSc Biotechnology, Aston University
  • 2006-2013 Senior Lecturer in Molecular Biology, Aston University
  • 2005-2006 LHS Innovation Fellow, Business Partnership Unit (partial secondment), Aston University
  • 2004-2005 CEO, ProtaMAX Ltd
  • 2003-2004 Medici Fellow (Commercialisation and Entrepreneurial Training)
  • 1995-2006 Lecturer in Molecular Biology, Aston University
  • 1993-94 Research Fellow, Harvard Medical School (PI: Prof. C.C. Richardson)

Qualifications

  • 1989-92 PhD, UMIST (Supervisor: Prof. T.A. Brown)
  • 1986-89 BSc Hons Biochemistry and Applied Molecular Biology (Class I) UMIST (now integrated into the University of Manchester)

Contact Details

Email: a.v.hine@aston.ac.uk 
Telephone: +44 (0) 121 204 3961

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

External positions

Panel Member, EPSRC Engineering prioritisation panel

2023

Member, Chairing Group, UKRI Technology Missions Fund, Engineering Biology Assessment College

2023 → …

Panel Member, BBSRC ICURe Options Roundabout

2022

Panel Chair, BBSRC Follow-on-fund

20212023

Panel Member, BBSRC Impact Accelerator Awards

2021

Panel Member, EPSRC International Centre to Centre Programme, UKRI-EPSRC

2019

Panel Member, BBSRC Impact Accelerator Awards, UKRI-BBSRC

2017

Panel Member, BBSRC Follow-on-Fund, UKRI-BBSRC

20162020

Panel Member, BBSRC Excellence with Impact, UKRI-BBSRC

2016

Consultant

20112013

Technical Expert, EU Eurostars programme

2009 → …

Member of EPSRC College, UKRI-EPSRC

2006 → …

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