Accepting PhD Students

    PhD projects

    - Mitochondrial targeting to address age-related conditions. Finding a better strategy for a better quality of life for the elderly.
    - 3Rs approaches to validate the safety of novel nanoparticle formulations by modelling human barriers in vitro
    - Nanoformulations targeting the mitochondria in in the treatment of epilepsy during pregnancy

    Personal profile

    Biography

    I joined Aston Medical School in 2020 as Lecturer in Bioenergetics, following a productive Research Fellowship position awarded the 50th Anniversary Aston Prize Fellowship in 2018 at Aston Medical School.

    My research focuses on understanding the role of mitochondria in the generation of energy in physiological and pathological conditions while elucidating mitochondrial molecular pathways and identifying targets for drug intervention in diverse areas of human disease. My passion for understanding metabolic routes linking mitochondrial bioenergetics and oxidative stress began during my PhD studies where I explored these complex concepts in models resembling cardiovascular complications of pregnancy, such as preeclampsia. Today, these interests have expanded to tackle other critical human disorders while understanding the importance of these signaling processes in health.

    Having experience in profiling the mitochondrial fingerprint in broad scenarios of cardiovascular and neuronal distress, I am currently exploring the development of formulations targeting intracellular compartments such as the mitochondria and exploring their potential to deliver cargo (drugs/inhibitors) to the mitochondria.

    Research Interests

    Targeting the mitochondria using nanoparticles:

    • Design and development of novel formulations targeting the mitochondria
    • Safety of formulations - Can we address mitochondrial dysfunction using nanoparticles as delivery systems?

    Investigating the role of cellular bioenergetics and metabolic dynamics in age-related disorders to identify novel molecular targets for therapeutic intervention.

    • Understanding the role of mitochondrial metabolism in cellular signalling, proliferation and cell growth.
    • Studying the effect of drugs in modulating cellular redox signalling, gene expression and metabolic pathways.

    Teaching Activity

    MBChB:

    Physiology and Pharmacology

    Reproductive System

    Metabolism, Endocrinology and Haematology

    Student Selected Component - Library-based research studies

    Qualifications

    Master in Education (Aston University), Birmingham, UK 2023

    Ph.D. Biomedical Sciences (Universidad del Valle) Cali, Colombia 2017

    Biochemistry and Clinical Laboratory Science (Universidad de Carabobo) Valencia, Venezuela 2009

    Membership of Professional Bodies

    Committee Member British Society for Cardiovascular Research, UK

    Fellow Higher Education Academy, UK

    Professional/editorial offices

    Scientific Grant Reviews Committees:

    Medical Research Council

    British Heart Foundation Grants Referee

    ColCiencias, Colombia Grants Referee

    University of Valle, Cali, Colombia

    Pontifical Xaverian University, Bogota, Colombia

    External Reviewer:

    Journal of Physiology and Biochemistry

    Funding Applications and Awards

    • BBSRC IAA Award 2023
    • Royal Society Grant - Round 2 - 2022
    • MIBTP Case Studentship, 2021
    • Sir Halley Stuart Small Grant Award, 2020

     

    Contact Details

    • Telephone: 01212045052
    • Email: l.sanchez-aranguren2@aston.ac.uk
    • Room Number: MB314E

    Expertise related to UN Sustainable Development Goals

    In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

    • SDG 3 - Good Health and Well-being

    Education/Academic qualification

    PhD, PhD in Biomedical Sciences, Universidad del Valle

    4 Feb 20136 Oct 2017

    Award Date: 6 Oct 2017

    Keywords

    • QP Physiology
    • Mitochondria
    • oxidative stress
    • RM Therapeutics. Pharmacology
    • Nanomaterials

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