Research output per year
Research output per year
Dr
Accepting PhD Students
PhD projects
Funded PhD Project through Midlands Integrative Biosciences Training Partnership (MIBTP)!
Open for applications: September 2024
Check eligibility and apply at: https://warwick.ac.uk/fac/cross_fac/mibtp/phd/application/
Open position for a motivated self-funded PhD student!
Available research projects on the effects of GTP depletion on gene expression, DNA damage and repair, as well as the molecular and cellular consequences of mutations in histone modifiers like KMT2D, KMT2C and JMJD6. Feel free to contact me if interested. Queries on published, related, interdisciplinary or novel projects are welcome.
https://www.findaphd.com/phds/project/novel-functions-of-the-hydroxylase-and-arginine-demethylase-jmjd6/?p152599
Dr Theo Kantidakis is a senior lecturer in Aston Medical School. He completed his undergraduate studies at the Biology department of Aristotle University of Thessaloniki, Greece, in 2002. He continued his education in the UK, by attending the MSc in Molecular Genetics at the University of Leicester, from which he graduated with distinction in 2003. Subsequently, he secured a prestigious 4-year PhD prize scholarship from the Wellcome Trust at the University of Glasgow (2003-2007), which fully funded his MRes and PhD research.
During his PhD, Dr Kantidakis worked on multiple aspects of the regulation of RNA polymerase III transcription in the lab of Prof. Bob White. He started his postdoctoral training at the Beatson Institute for Cancer Research (2008-2010) and showed how mTOR can affect tRNA transcription by phosphorylation of transcriptional repressor MAF1.
Next, Dr Kantidakis moved to Cancer Research UK’s London Research Institute (now Francis Crick Institute) to continue his postdoctoral studies (2010-2016) with Prof. Jesper Svejstrup, working on the interface of RNA polymerase II transcription, chromatin epigenetics and the maintenance of genomic stability. By employing several of the latest genome-wide techniques, he discovered, among others, that inactivation of MLL2 (KMT2D), a histone methyltransferase that is often mutated in many cancers, results in transcription stress, DNA damage and genomic instability, providing a mechanism to explain its widespread role as a cancer driver.
In 2016, Dr Kantidakis moved to Xi’an Jiaotong-Liverpool University (XJTLU) in China, where he taught at the department of Biological Sciences. In 2018, he moved back to UK and joined the newly established Aston Medical School (AMS).
Dr Kantidakis' research has been published in many prestigious journals, including Cell, Genes & Development, PNAS, Nucleic Acids Research. His current research focus is on chromatin and transcription regulation, investigating their role in DNA damage and genomic stability.
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review