A duration-dependent interaction between high-intensity light and optical refocus in the drive for myopia control

Sayantan Biswas; Arumugam R. Muralidharan; Bjorn Kaijun Betzler; Joanna Marie Fianza Busoy; Veluchamy A. Barathi; Royston K. Y. Tan; Wan Yu Shermaine Low; Dan Milea; Biten K. Kathrani; Noel A. Brennan; Raymond P. Najjar

doi:10.1101/2022.12.19.520946

A duration-dependent interaction between high-intensity light and optical refocus in the drive for myopia control

Sayantan Biswas, Arumugam R. Muralidharan, Bjorn Kaijun Betzler, Joanna Marie Fianza Busoy, Veluchamy A. Barathi, Royston K. Y. Tan, Wan Yu Shermaine Low, Dan Milea, Biten K. Kathrani, Noel A. Brennan, Raymond P. Najjar

Research output: Preprint or Working paper › Preprint

Abstract

PURPOSE To evaluate the duration-dependent and synergetic impact of high-intensity light (HL) and optical refocus (RF) on lens-induced myopia (LIM) development in chickens.

METHODS Myopia was induced in one eye in chicks (10 groups, n=126) from day 1 post- hatching (D1) until D8 using -10D lenses. Fellow eyes remained uncovered as controls. Nine groups were exposed daily to continuous 2 hours (h), 4h, or 6h of either HL (15,000 lux); RF (removal of -10D lens); or both (HL+RF). One group served as the LIM group without any interventions. Ocular axial length (AL), refractive error, and choroidal thickness were measured on D1, D4, and D8. Outcome measures are expressed as inter-ocular difference (IOD= experimental - control eye) ±SEM.

RESULTS By D8, LIM increased AL (0.36±0.04 mm), myopic refraction (-9.02±0.37D), and choroidal thinning (-90.27±16.44 µm) in the LIM group (all, P
CONCLUSION Daily exposure to 2h, 4h, or 6h of HL, RF, or HL+RF reduced lens-induced myopic refraction in a duration-dependent manner in chickens. Only 6h of HL+RF completely stopped LIM development. The synergetic effect of HL and RF is dependent on the duration of the interventions.

Original language	English
Number of pages	33
DOIs	https://doi.org/10.1101/2022.12.19.520946
Publication status	Published - 19 Dec 2022

Bibliographical note

Copyright 2019 The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

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Biswasetal_2019_PP
Copyright 2019 The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Cite this

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title = "A duration-dependent interaction between high-intensity light and optical refocus in the drive for myopia control",

abstract = "PURPOSE To evaluate the duration-dependent and synergetic impact of high-intensity light (HL) and optical refocus (RF) on lens-induced myopia (LIM) development in chickens.METHODS Myopia was induced in one eye in chicks (10 groups, n=126) from day 1 post- hatching (D1) until D8 using -10D lenses. Fellow eyes remained uncovered as controls. Nine groups were exposed daily to continuous 2 hours (h), 4h, or 6h of either HL (15,000 lux); RF (removal of -10D lens); or both (HL+RF). One group served as the LIM group without any interventions. Ocular axial length (AL), refractive error, and choroidal thickness were measured on D1, D4, and D8. Outcome measures are expressed as inter-ocular difference (IOD= experimental - control eye) ±SEM.RESULTS By D8, LIM increased AL (0.36±0.04 mm), myopic refraction (-9.02±0.37D), and choroidal thinning (-90.27±16.44 µm) in the LIM group (all, PCONCLUSION Daily exposure to 2h, 4h, or 6h of HL, RF, or HL+RF reduced lens-induced myopic refraction in a duration-dependent manner in chickens. Only 6h of HL+RF completely stopped LIM development. The synergetic effect of HL and RF is dependent on the duration of the interventions.",

author = "Sayantan Biswas and Muralidharan, {Arumugam R.} and Betzler, {Bjorn Kaijun} and Busoy, {Joanna Marie Fianza} and Barathi, {Veluchamy A.} and Tan, {Royston K. Y.} and Low, {Wan Yu Shermaine} and Dan Milea and Kathrani, {Biten K.} and Brennan, {Noel A.} and Najjar, {Raymond P.}",

note = "Copyright 2019 The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.",

year = "2022",

month = dec,

day = "19",

doi = "10.1101/2022.12.19.520946",

language = "English",

type = "WorkingPaper",

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T1 - A duration-dependent interaction between high-intensity light and optical refocus in the drive for myopia control

AU - Biswas, Sayantan

AU - Muralidharan, Arumugam R.

AU - Betzler, Bjorn Kaijun

AU - Busoy, Joanna Marie Fianza

AU - Barathi, Veluchamy A.

AU - Tan, Royston K. Y.

AU - Low, Wan Yu Shermaine

AU - Milea, Dan

AU - Kathrani, Biten K.

AU - Brennan, Noel A.

AU - Najjar, Raymond P.

N1 - Copyright 2019 The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

PY - 2022/12/19

Y1 - 2022/12/19

N2 - PURPOSE To evaluate the duration-dependent and synergetic impact of high-intensity light (HL) and optical refocus (RF) on lens-induced myopia (LIM) development in chickens.METHODS Myopia was induced in one eye in chicks (10 groups, n=126) from day 1 post- hatching (D1) until D8 using -10D lenses. Fellow eyes remained uncovered as controls. Nine groups were exposed daily to continuous 2 hours (h), 4h, or 6h of either HL (15,000 lux); RF (removal of -10D lens); or both (HL+RF). One group served as the LIM group without any interventions. Ocular axial length (AL), refractive error, and choroidal thickness were measured on D1, D4, and D8. Outcome measures are expressed as inter-ocular difference (IOD= experimental - control eye) ±SEM.RESULTS By D8, LIM increased AL (0.36±0.04 mm), myopic refraction (-9.02±0.37D), and choroidal thinning (-90.27±16.44 µm) in the LIM group (all, PCONCLUSION Daily exposure to 2h, 4h, or 6h of HL, RF, or HL+RF reduced lens-induced myopic refraction in a duration-dependent manner in chickens. Only 6h of HL+RF completely stopped LIM development. The synergetic effect of HL and RF is dependent on the duration of the interventions.

AB - PURPOSE To evaluate the duration-dependent and synergetic impact of high-intensity light (HL) and optical refocus (RF) on lens-induced myopia (LIM) development in chickens.METHODS Myopia was induced in one eye in chicks (10 groups, n=126) from day 1 post- hatching (D1) until D8 using -10D lenses. Fellow eyes remained uncovered as controls. Nine groups were exposed daily to continuous 2 hours (h), 4h, or 6h of either HL (15,000 lux); RF (removal of -10D lens); or both (HL+RF). One group served as the LIM group without any interventions. Ocular axial length (AL), refractive error, and choroidal thickness were measured on D1, D4, and D8. Outcome measures are expressed as inter-ocular difference (IOD= experimental - control eye) ±SEM.RESULTS By D8, LIM increased AL (0.36±0.04 mm), myopic refraction (-9.02±0.37D), and choroidal thinning (-90.27±16.44 µm) in the LIM group (all, PCONCLUSION Daily exposure to 2h, 4h, or 6h of HL, RF, or HL+RF reduced lens-induced myopic refraction in a duration-dependent manner in chickens. Only 6h of HL+RF completely stopped LIM development. The synergetic effect of HL and RF is dependent on the duration of the interventions.

UR - https://doi.org/10.1101/2022.12.19.520946

UR - https://www.biorxiv.org/content/10.1101/2022.12.19.520946v1

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DO - 10.1101/2022.12.19.520946

M3 - Preprint

BT - A duration-dependent interaction between high-intensity light and optical refocus in the drive for myopia control

ER -

A duration-dependent interaction between high-intensity light and optical refocus in the drive for myopia control

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