Acute and long-term effects of metformin on the function and insulin secretory responsiveness of clonal β-cells

Joan M. McKiney; Nigel Irwin; Peter R. Flatt; Clifford J. Bailey; Neville H. McClenaghan

doi:10.1515/BC.2010.139

Acute and long-term effects of metformin on the function and insulin secretory responsiveness of clonal β-cells

Joan M. McKiney, Nigel Irwin, Peter R. Flatt, Clifford J. Bailey, Neville H. McClenaghan

Research output: Contribution to journal › Article › peer-review

Abstract

Functional effects of acute and prolonged (48 h) exposure to the biguanide drug metformin were examined in the clonal pancreatic ß-cell line, BRIN-BD11. Effects of metformin on prolonged exposure to excessive increased concentrations of glucose and palmitic acid were also assessed. In acute 20-min incubations, 12.5-50 µm metformin did not alter basal (1.1 mm glucose) or glucose-stimulated (16.7 mm glucose) insulin secretion. However, higher concentrations of metformin (100-1000 µm) increased (1.3-1.5-fold; p

Original language	English
Pages (from-to)	1451-1459
Number of pages	9
Journal	Biological Chemistry
Volume	391
Issue number	12
DOIs	https://doi.org/10.1515/BC.2010.139
Publication status	Published - Dec 2010

Keywords

animals
calcium
cell survival
cultured cells
drug dose-response relationship
gene expression
glucose
hypoglycemic agents
insulin
insulin-secreting cells
islets of Langerhans
metformin
palmitic acid
rats
time factors

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10.1515/BC.2010.139

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keywords = "animals, calcium, cell survival, cultured cells, drug dose-response relationship, gene expression, glucose, hypoglycemic agents, insulin, insulin-secreting cells, islets of Langerhans, metformin, palmitic acid, rats, time factors",

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AU - Irwin, Nigel

AU - Flatt, Peter R.

AU - Bailey, Clifford J.

AU - McClenaghan, Neville H.

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KW - calcium

KW - cell survival

KW - cultured cells

KW - drug dose-response relationship

KW - gene expression

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KW - hypoglycemic agents

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Acute and long-term effects of metformin on the function and insulin secretory responsiveness of clonal β-cells

Abstract

Keywords

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