Administration of growth factors for bone regeneration

Ye-Rang Yun, Jun Hyeog Jang, Eunyi Jeon, Wonmo Kang, Sujin Lee, Jong-Eun Won, Hae Won Kim, Ivan Wall

Research output: Contribution to journalReview articlepeer-review


Growth factors (GFs) such as BMPs, FGFs, VEGFs and IGFs have significant impacts on osteoblast behavior, and thus have been widely utilized for bone tissue regeneration. Recently, securing biological stability for a sustainable and controllable release to the target tissue has been a challenge to practical applications. This challenge has been addressed to some degree with the development of appropriate carrier materials and delivery systems. This review highlights the importance and roles of those GFs, as well as their proper administration for targeting bone regeneration. Additionally, the in vitro and in vivo performance of those GFs with or without the use of carrier systems in the repair and regeneration of bone tissue is systematically addressed. Moreover, some recent advances in the utility of the GFs, such as using fusion technology, are also reviewed.

Original languageEnglish
Pages (from-to)369-85
Number of pages17
JournalRegenerative medicine
Issue number3
Publication statusPublished - May 2012

Bibliographical note

© 2019 Future Science Group.


  • Animals
  • Bone Regeneration/drug effects
  • Drug Carriers/chemistry
  • Drug Delivery Systems/methods
  • Drug and Narcotic Control
  • Humans
  • Intercellular Signaling Peptides and Proteins/administration & dosage
  • Translational Medical Research/legislation & jurisprudence


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