Advances in Dynamic Light Scattering Imaging of Blood Flow

Anton Sdobnov, Gennadii A. Piavchenko, Alexander V. Bykov, Igor Meglinski*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Dynamic light scattering (DLS) is a well known experimental approach uniquely suited for the characterization of small particles undergoing Brownian motion in randomly inhomogeneous turbid scattering medium, including water suspension, polymers in solutions, cells cultures, and so on. DLS is based on the illuminating of turbid medium with a coherent laser light and further analyzes the intensity fluctuations caused by the motion of the scattering particles. The DLS-based spin-off derivative techniques, such laser Doppler flowmetry (LDF), diffusing wave spectroscopy (DWS), laser speckle contrast imaging (LSCI), and Doppler optical coherence tomography (DOCT), are exploited widely for non-invasive imaging of blood flow in brain, skin, muscles, and other biological tissues. The recent advancements in the DLS-based imaging technologies in frame of their application for brain blood flow monitoring, skin perfusion measurements, and non-invasive blood micro-circulation characterization are overviewed. The fundamentals, breakthrough potential, and practical findings revealed by DLS-based blood flow imaging studies, including the limitations and challenges of the approach such as movement artifacts, non-ergodicity, and overcoming high scattering properties of studied medium, are also discussed. It is concluded that continued research and further technological advancements in DLS-based imaging will pave the way for new exciting developments and insights into blood flow diagnostic imaging.
Original languageEnglish
Article number2300494
JournalLaser and Photonics Reviews
Early online date27 Nov 2023
Publication statusE-pub ahead of print - 27 Nov 2023

Bibliographical note

© 2023 The Authors. Laser & Photonics Reviews published by Wiley-VCH GmbH

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Funding: European Union’s Horizon 2020 research and innovation programme - 863214; Russian Science Foundation - 22-65-00096


  • Doppler optical coherence tomography
  • blood flow
  • diffusing wave spectroscopy
  • dynamic light scattering
  • laser Doppler flowmetry
  • laser speckle contrast imaging
  • microcirculation


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