Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery

Peter C. Seville; Tristan P. Learoyd; Hao-Ying Li; I.J. Williamson; James C. Birchall

doi:10.1016/j.powtec.2007.03.046

Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery

Peter C. Seville^*, Tristan P. Learoyd, Hao-Ying Li, I.J. Williamson, James C. Birchall

^*Corresponding author for this work

Aston Pharmacy School

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, the amino acids arginine, aspartic acid, leucine, phenylalanine and threonine were investigated as 'dispersibility enhancers' in spray-dried powders for inhalation. Parameters such as spray-dried yield, tapped density, and Carr's Index were not predictive of aerosolisation performance. In addition, whilst the majority of amino acid-modified powders displayed suitable particle size distribution for pulmonary administration and potentially favourable low moisture content, in vitro particle deposition was only enhanced for the leucine-modified powder. In summary, leucine can be used to enhance the dispersibility and aerosolisation properties of spray-dried powders for pulmonary drug delivery. © 2007 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	40-50
Number of pages	11
Journal	Powder Technology
Volume	178
Issue number	1
DOIs	https://doi.org/10.1016/j.powtec.2007.03.046
Publication status	Published - 5 Sept 2007

Keywords

amino acids
dispersibility
pulmonary deposition
salbutamol sulphate
spray-drying

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10.1016/j.powtec.2007.03.046

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title = "Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery",

abstract = "In this study, the amino acids arginine, aspartic acid, leucine, phenylalanine and threonine were investigated as 'dispersibility enhancers' in spray-dried powders for inhalation. Parameters such as spray-dried yield, tapped density, and Carr's Index were not predictive of aerosolisation performance. In addition, whilst the majority of amino acid-modified powders displayed suitable particle size distribution for pulmonary administration and potentially favourable low moisture content, in vitro particle deposition was only enhanced for the leucine-modified powder. In summary, leucine can be used to enhance the dispersibility and aerosolisation properties of spray-dried powders for pulmonary drug delivery. {\textcopyright} 2007 Elsevier B.V. All rights reserved.",

keywords = "amino acids, dispersibility, pulmonary deposition, salbutamol sulphate, spray-drying",

author = "Seville, {Peter C.} and Learoyd, {Tristan P.} and Hao-Ying Li and I.J. Williamson and Birchall, {James C.}",

year = "2007",

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doi = "10.1016/j.powtec.2007.03.046",

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T1 - Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery

AU - Seville, Peter C.

AU - Learoyd, Tristan P.

AU - Li, Hao-Ying

AU - Williamson, I.J.

AU - Birchall, James C.

PY - 2007/9/5

Y1 - 2007/9/5

N2 - In this study, the amino acids arginine, aspartic acid, leucine, phenylalanine and threonine were investigated as 'dispersibility enhancers' in spray-dried powders for inhalation. Parameters such as spray-dried yield, tapped density, and Carr's Index were not predictive of aerosolisation performance. In addition, whilst the majority of amino acid-modified powders displayed suitable particle size distribution for pulmonary administration and potentially favourable low moisture content, in vitro particle deposition was only enhanced for the leucine-modified powder. In summary, leucine can be used to enhance the dispersibility and aerosolisation properties of spray-dried powders for pulmonary drug delivery. © 2007 Elsevier B.V. All rights reserved.

AB - In this study, the amino acids arginine, aspartic acid, leucine, phenylalanine and threonine were investigated as 'dispersibility enhancers' in spray-dried powders for inhalation. Parameters such as spray-dried yield, tapped density, and Carr's Index were not predictive of aerosolisation performance. In addition, whilst the majority of amino acid-modified powders displayed suitable particle size distribution for pulmonary administration and potentially favourable low moisture content, in vitro particle deposition was only enhanced for the leucine-modified powder. In summary, leucine can be used to enhance the dispersibility and aerosolisation properties of spray-dried powders for pulmonary drug delivery. © 2007 Elsevier B.V. All rights reserved.

KW - amino acids

KW - dispersibility

KW - pulmonary deposition

KW - salbutamol sulphate

KW - spray-drying

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DO - 10.1016/j.powtec.2007.03.046

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JO - Powder Technology

JF - Powder Technology

IS - 1

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Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery

Abstract

Keywords

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