Analysis of irises with a latanoprost-induced change in iris color

Esther Arranz-Marquez; Miguel A. Teus; M. Antonia Saornil; M. Carmen Mendez; Raquel Gil

doi:10.1016/j.ajo.2004.06.017

Analysis of irises with a latanoprost-induced change in iris color

Esther Arranz-Marquez, Miguel A. Teus, M. Antonia Saornil, M. Carmen Mendez, Raquel Gil

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose

To study the histologic aspects of irises subjected to extended latanoprost treatment.

Design

Prospective, observer-masked study.

Methods

Iris biopsies of eyes treated with latanoprost were analyzed (all had a photographically documented increase in iris pigmentation) plus control eyes (untreated with prostanoids) using optical microscopy. patient or study population: There were 14 study eyes treated with latanoprost and 8 untreated control eyes. main outcome measure: The morphologic characteristics of the irises.

Results

The irises treated with latanoprost had an increased number of melanocytes with nuclear inclusions, granules of melanin in the vascular walls and the melanocytes and free granules in the stroma compared with control eyes (P = .001, P = .01, P = .004, P = .01, respectively, by the χ2 test).

Conclusions

Chronic therapy with latanoprost appears to induce more changes in the iris than a simple increase in the melanin content of the melanocytes.

Original language	English
Pages (from-to)	625-630
Number of pages	6
Journal	American Journal of Ophthalmology
Volume	138
Issue number	4
Early online date	15 Sept 2004
DOIs	https://doi.org/10.1016/j.ajo.2004.06.017
Publication status	Published - Oct 2004

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10.1016/j.ajo.2004.06.017

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@article{45b84d8e15c5424280614f2bec0a71fa,

title = "Analysis of irises with a latanoprost-induced change in iris color",

abstract = "PurposeTo study the histologic aspects of irises subjected to extended latanoprost treatment.DesignProspective, observer-masked study.MethodsIris biopsies of eyes treated with latanoprost were analyzed (all had a photographically documented increase in iris pigmentation) plus control eyes (untreated with prostanoids) using optical microscopy. patient or study population: There were 14 study eyes treated with latanoprost and 8 untreated control eyes. main outcome measure: The morphologic characteristics of the irises.ResultsThe irises treated with latanoprost had an increased number of melanocytes with nuclear inclusions, granules of melanin in the vascular walls and the melanocytes and free granules in the stroma compared with control eyes (P = .001, P = .01, P = .004, P = .01, respectively, by the χ2 test).ConclusionsChronic therapy with latanoprost appears to induce more changes in the iris than a simple increase in the melanin content of the melanocytes.",

author = "Esther Arranz-Marquez and Teus, {Miguel A.} and Saornil, {M. Antonia} and Mendez, {M. Carmen} and Raquel Gil",

year = "2004",

month = oct,

doi = "10.1016/j.ajo.2004.06.017",

language = "English",

volume = "138",

pages = "625--630",

journal = "American Journal of Ophthalmology",

issn = "0002-9394",

publisher = "Elsevier",

number = "4",

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TY - JOUR

T1 - Analysis of irises with a latanoprost-induced change in iris color

AU - Arranz-Marquez, Esther

AU - Teus, Miguel A.

AU - Saornil, M. Antonia

AU - Mendez, M. Carmen

AU - Gil, Raquel

PY - 2004/10

Y1 - 2004/10

N2 - PurposeTo study the histologic aspects of irises subjected to extended latanoprost treatment.DesignProspective, observer-masked study.MethodsIris biopsies of eyes treated with latanoprost were analyzed (all had a photographically documented increase in iris pigmentation) plus control eyes (untreated with prostanoids) using optical microscopy. patient or study population: There were 14 study eyes treated with latanoprost and 8 untreated control eyes. main outcome measure: The morphologic characteristics of the irises.ResultsThe irises treated with latanoprost had an increased number of melanocytes with nuclear inclusions, granules of melanin in the vascular walls and the melanocytes and free granules in the stroma compared with control eyes (P = .001, P = .01, P = .004, P = .01, respectively, by the χ2 test).ConclusionsChronic therapy with latanoprost appears to induce more changes in the iris than a simple increase in the melanin content of the melanocytes.

AB - PurposeTo study the histologic aspects of irises subjected to extended latanoprost treatment.DesignProspective, observer-masked study.MethodsIris biopsies of eyes treated with latanoprost were analyzed (all had a photographically documented increase in iris pigmentation) plus control eyes (untreated with prostanoids) using optical microscopy. patient or study population: There were 14 study eyes treated with latanoprost and 8 untreated control eyes. main outcome measure: The morphologic characteristics of the irises.ResultsThe irises treated with latanoprost had an increased number of melanocytes with nuclear inclusions, granules of melanin in the vascular walls and the melanocytes and free granules in the stroma compared with control eyes (P = .001, P = .01, P = .004, P = .01, respectively, by the χ2 test).ConclusionsChronic therapy with latanoprost appears to induce more changes in the iris than a simple increase in the melanin content of the melanocytes.

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UR - https://www.ajo.com/article/S0002-9394(04)00673-7/fulltext

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AN - SCOPUS:7044237146

SN - 0002-9394

VL - 138

SP - 625

EP - 630

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

IS - 4

ER -

Analysis of irises with a latanoprost-induced change in iris color

Abstract

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