Angiotensin II directly induces muscle protein catabolism through the ubiquitin-proteasome proteolytic pathway and may play a role in cancer cachexia

Keyphrases

• Cancer Cachexia 100%
• Proteolytic Cascade 100%
• Protein Catabolism 100%
• Ubiquitin-proteasome System 100%
• Muscle Protein 100%
• Role in Cancer 100%
• Angiotensin II (Ang II) 100%
• Protein Degradation 75%
• Angiotensin I 50%
• Myotubes 16%
• Dose-response Curve 16%
• Maximal Effect 16%
• Angiotensin-converting Enzyme Inhibitor (ACEi) 16%
• Imidaprilat 16%
• Growth Factors 8%
• Insulin-like 8%
• Skeletal muscle 8%
• Tumor 8%
• Protein Expression 8%
• Cancer Research 8%
• Cachexia 8%
• Muscle Atrophy 8%
• Eicosapentaenoic Acid 8%
• Weight Loss 8%
• Polyunsaturated Fatty Acids 8%
• 20S Proteasome 8%
• Chymotrypsin 8%
• Enzyme Activity 8%
• Proteasome Subunits 8%
• Lactacystin 8%
• Protease Inhibitors 8%
• Lipophilic 8%
• Total Protein 8%
• Co-incubation 8%
• MG132 8%
• Imidapril 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Proteasome 100%
• Cachexia 100%
• Ubiquitin 100%
• Muscle Protein 100%
• Angiotensin II 100%
• Angiotensin I 100%
• Dipeptidyl Carboxypeptidase Inhibitor 33%
• Imidaprilat 33%
• Mouse 16%
• Neoplasm 16%
• Muscle Atrophy 16%
• Malignant Neoplasm 16%
• Protein 16%
• Icosapentaenoic Acid 16%
• Polyunsaturated Fatty Acid 16%
• Chymotrypsin 16%
• Murine 16%
• Lactacystin 16%
• Proteasome Inhibitor 16%
• Somatomedin 16%
• Benzyloxycarbonylleucylleucylleucinal 16%
• Imidapril 16%

Biochemistry, Genetics and Molecular Biology

• Angiotensin 100%
• Protein Catabolism 100%
• Proteasome 100%
• Ubiquitin 100%
• Dose Response 20%
• Angiotensin-Converting Enzyme 20%
• Enzyme Inhibitor 20%
• Mouse 10%
• Skeletal Muscle 10%
• Eicosapentaenoic Acid 10%
• Upregulation 10%
• Chymotrypsin 10%
• Polyunsaturated Fatty Acid 10%
• Enzyme Activity 10%
• Protein Expression 10%
• Proteasome Inhibitor 10%
• Murine 10%
• MG132 10%
• Insulin-Like Growth Factor 10%