Antibacterial activity of 3-substituted pyrrole-2,5-diones against Pseudomonas aeruginosa

Eric Lattmann*, Simon Dunn, Suwanna Niamsanit, Jintana Sattayasai, Nison Sattayasai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


3-Substituted pyrrole-2,5-diones were synthesised from mucohalogen acids and the antibacterial activity was subsequently determined in biological assays. The minimum inhibitory concentration and the minimum bactericidal concentration of 2a were determined for a wide range of microorganisms in the low micromolar range. Protein identification using SDS-PAGE and LC/MS/MS demonstrated a partly degradation of OprF-related proteins giving an insight into the underlying mechanism of these novel antibacterial agents. © 2007 Bentham Science Publishers Ltd.

Original languageEnglish
Pages (from-to)513-519
Number of pages7
JournalLetters in Drug Design and Discovery
Issue number7
Publication statusPublished - Oct 2007


  • antibacterial
  • halogenated pyrrole
  • oprF-related protein
  • pseudomonas aeruginosa


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