TY - JOUR
T1 - Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function
AU - Jackson, Malcolm J.
AU - Papa, Sergio
AU - Bolaños, Juan
AU - Bruckdorfer, Richard
AU - Carlsen, Harald
AU - Elliott, Ruan M
AU - Flier, Jacoba
AU - Griffiths, Helen R.
AU - Heales, Simon
AU - Holst, Birgit
AU - Lorusso, Michele
AU - Lund, Elizabeth
AU - Øivind Moskaug, Jan
AU - Moser, Ulrich
AU - Di Paola, Marco
AU - Polidori, M Cristina
AU - Signorile, Anna
AU - Stahl, Wilhelm
AU - Viña-Ribes, José
AU - Astley, Siân B.
PY - 2002/2
Y1 - 2002/2
N2 - Redox-sensitive cell signalling
Thiol groups and the regulation of gene expression
Redox-sensitive signal transduction pathways
Protein kinases
Protein phosphatases
Lipids and phospholipases
Antioxidant (electrophile) response element
Intracellular calcium signalling
Transcription factors
NF-?B
AP-1
p53
Cellular responses to oxidative stress
Cellular responses to change in redox state
Proliferation
Cell death
Immune cell function
Reactive oxygen and nitrogen species – good or bad?
Reactive oxygen species and cell death
Reactive oxygen species and inflammation
Are specific reactive oxygen species and antioxidants involved in modulating cellular responses?
Specific effects of dietary antioxidants in cell regulation
Carotenoids
Vitamin E
Flavonoids
Inducers of phase II enzymes
Disease states affected
Oxidants, antioxidants and mitochondria
Introduction
Mitochondrial generation of reactive oxygen and nitrogen species
Mitochondria and apoptosis
Mitochondria and antioxidant defences
Key role of mitochondrial GSH in the defence against oxidative damage
Mitochondrial oxidative damage
Direct oxidative damage to the mitochondrial electron transport chain
Nitric oxide and damage to mitochondria
Effects of nutrients on mitochondria
Caloric restriction and antioxidants
Lipids
Antioxidants
Techniques and approaches
Mitochondrial techniques
cDNA microarray approaches
Proteomics approaches
Transgenic mice as tools in antioxidant research
Gene knockout and over expression
Transgenic reporter mice
Conclusions
Future research needs
AB - Redox-sensitive cell signalling
Thiol groups and the regulation of gene expression
Redox-sensitive signal transduction pathways
Protein kinases
Protein phosphatases
Lipids and phospholipases
Antioxidant (electrophile) response element
Intracellular calcium signalling
Transcription factors
NF-?B
AP-1
p53
Cellular responses to oxidative stress
Cellular responses to change in redox state
Proliferation
Cell death
Immune cell function
Reactive oxygen and nitrogen species – good or bad?
Reactive oxygen species and cell death
Reactive oxygen species and inflammation
Are specific reactive oxygen species and antioxidants involved in modulating cellular responses?
Specific effects of dietary antioxidants in cell regulation
Carotenoids
Vitamin E
Flavonoids
Inducers of phase II enzymes
Disease states affected
Oxidants, antioxidants and mitochondria
Introduction
Mitochondrial generation of reactive oxygen and nitrogen species
Mitochondria and apoptosis
Mitochondria and antioxidant defences
Key role of mitochondrial GSH in the defence against oxidative damage
Mitochondrial oxidative damage
Direct oxidative damage to the mitochondrial electron transport chain
Nitric oxide and damage to mitochondria
Effects of nutrients on mitochondria
Caloric restriction and antioxidants
Lipids
Antioxidants
Techniques and approaches
Mitochondrial techniques
cDNA microarray approaches
Proteomics approaches
Transgenic mice as tools in antioxidant research
Gene knockout and over expression
Transgenic reporter mice
Conclusions
Future research needs
UR - http://www.scopus.com/inward/record.url?scp=0036088349&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/pii/S0098299702000183?via%3Dihub
U2 - 10.1016/S0098-2997(02)00018-3
DO - 10.1016/S0098-2997(02)00018-3
M3 - Article
C2 - 12079772
SN - 0098-2997
VL - 23
SP - 209
EP - 285
JO - Molecular Aspects of Medicine
JF - Molecular Aspects of Medicine
IS - 1-3
ER -