Apoptosis of neurons and oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy): possible pathomechanism of human cervical compressive myelopathy

Kenzo Uchida; Hideaki Nakajima; Shuji Watanabe; Takafumi Yayama; Alexander R. Guerrero; Tomoo Inukai; Takayuki Hirai; Daisuke Sugita; William E Johnson; Hisatoshi Baba

doi:10.1007/s00586-011-2025-x

Apoptosis of neurons and oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy): possible pathomechanism of human cervical compressive myelopathy

Kenzo Uchida, Hideaki Nakajima, Shuji Watanabe, Takafumi Yayama, Alexander R. Guerrero, Tomoo Inukai, Takayuki Hirai, Daisuke Sugita, William E Johnson, Hisatoshi Baba

Research output: Contribution to journal › Article › peer-review

Abstract

Cervical compressive myelopathy is the most serious complication of cervical spondylosis or ossification of the posterior longitudinal ligament (OPLL) and the most frequent cause of spinal cord dysfunction. There is little information on the exact pathophysiological mechanism responsible for the progressive loss of neural tissue in the spinal cord of such patients. In this study, we used the spinal hyperostotic mouse (twy/twy) as a suitable model of human spondylosis, and OPLL to investigate the cellular and molecular changes in the spinal cord. Mutant twy/twy mouse developed ossification of the ligamentum flavum at C2-C3 and exhibited progressive paralysis.

Original language	English
Pages (from-to)	490-497
Number of pages	8
Journal	European Spine Journal
Volume	21
Issue number	3
DOIs	https://doi.org/10.1007/s00586-011-2025-x
Publication status	Published - Mar 2012

Bibliographical note

Creative Commons Attribution. © The Author(s) 2011.
The original publication is available at www.springerlink.com

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10.1007/s00586-011-2025-x

Apoptosis of neurons and oligodendrocytes
Creative Commons Attribution. The Author(s) 2011. The original publication is available at www.springerlink.com
Final published version, 596 KBLicence: CC BY 3.0

http://www.springerlink.com/content/u022ggq103411194/

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Uchida, K., Nakajima, H., Watanabe, S., Yayama, T., Guerrero, A. R., Inukai, T., Hirai, T., Sugita, D., Johnson, W. E., & Baba, H. (2012). Apoptosis of neurons and oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy): possible pathomechanism of human cervical compressive myelopathy. European Spine Journal, 21(3), 490-497. https://doi.org/10.1007/s00586-011-2025-x

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title = "Apoptosis of neurons and oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy): possible pathomechanism of human cervical compressive myelopathy",

abstract = "Cervical compressive myelopathy is the most serious complication of cervical spondylosis or ossification of the posterior longitudinal ligament (OPLL) and the most frequent cause of spinal cord dysfunction. There is little information on the exact pathophysiological mechanism responsible for the progressive loss of neural tissue in the spinal cord of such patients. In this study, we used the spinal hyperostotic mouse (twy/twy) as a suitable model of human spondylosis, and OPLL to investigate the cellular and molecular changes in the spinal cord. Mutant twy/twy mouse developed ossification of the ligamentum flavum at C2-C3 and exhibited progressive paralysis.",

author = "Kenzo Uchida and Hideaki Nakajima and Shuji Watanabe and Takafumi Yayama and Guerrero, {Alexander R.} and Tomoo Inukai and Takayuki Hirai and Daisuke Sugita and Johnson, {William E} and Hisatoshi Baba",

note = "Creative Commons Attribution. {\textcopyright} The Author(s) 2011. The original publication is available at www.springerlink.com",

year = "2012",

month = mar,

doi = "10.1007/s00586-011-2025-x",

language = "English",

volume = "21",

pages = "490--497",

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Uchida, K, Nakajima, H, Watanabe, S, Yayama, T, Guerrero, AR, Inukai, T, Hirai, T, Sugita, D, Johnson, WE & Baba, H 2012, 'Apoptosis of neurons and oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy): possible pathomechanism of human cervical compressive myelopathy', European Spine Journal, vol. 21, no. 3, pp. 490-497. https://doi.org/10.1007/s00586-011-2025-x

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T2 - possible pathomechanism of human cervical compressive myelopathy

AU - Uchida, Kenzo

AU - Nakajima, Hideaki

AU - Watanabe, Shuji

AU - Yayama, Takafumi

AU - Guerrero, Alexander R.

AU - Inukai, Tomoo

AU - Hirai, Takayuki

AU - Sugita, Daisuke

AU - Johnson, William E

AU - Baba, Hisatoshi

PY - 2012/3

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N2 - Cervical compressive myelopathy is the most serious complication of cervical spondylosis or ossification of the posterior longitudinal ligament (OPLL) and the most frequent cause of spinal cord dysfunction. There is little information on the exact pathophysiological mechanism responsible for the progressive loss of neural tissue in the spinal cord of such patients. In this study, we used the spinal hyperostotic mouse (twy/twy) as a suitable model of human spondylosis, and OPLL to investigate the cellular and molecular changes in the spinal cord. Mutant twy/twy mouse developed ossification of the ligamentum flavum at C2-C3 and exhibited progressive paralysis.

AB - Cervical compressive myelopathy is the most serious complication of cervical spondylosis or ossification of the posterior longitudinal ligament (OPLL) and the most frequent cause of spinal cord dysfunction. There is little information on the exact pathophysiological mechanism responsible for the progressive loss of neural tissue in the spinal cord of such patients. In this study, we used the spinal hyperostotic mouse (twy/twy) as a suitable model of human spondylosis, and OPLL to investigate the cellular and molecular changes in the spinal cord. Mutant twy/twy mouse developed ossification of the ligamentum flavum at C2-C3 and exhibited progressive paralysis.

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DO - 10.1007/s00586-011-2025-x

M3 - Article

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SN - 0940-6719

VL - 21

SP - 490

EP - 497

JO - European Spine Journal

JF - European Spine Journal

IS - 3

ER -

Apoptosis of neurons and oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy): possible pathomechanism of human cervical compressive myelopathy

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