AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation

Betul Cicek, Ahmet Hacimuftuoglu, Yesim Yeni, Mehmet Kuzucu, Sidika Genc, Ahmet Cetin, Emre Yavuz, Betul Danısman, Akin Levent, Kemal Volkan Ozdokur, Mecit Kantarcı, Anca Oana Docea, Vasileios Siokas, Konstantinos Tsarouhas, Michael D Coleman, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi

Research output: Contribution to journalArticlepeer-review

Abstract

The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO ) for 21 days. 10 µg/g AuNPs, 1.6 g/kg CS, and 10 µg/g CS-AuNPs were administered orally simultaneously with 10 mg/kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-α and IL-1β levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments. [Abstract copyright: Copyright © 2024 Elsevier B.V. All rights reserved.]
Original languageEnglish
Article number104417
Number of pages11
JournalEnvironmental Toxicology and Pharmacology
Volume107
Early online date15 Mar 2024
DOIs
Publication statusPublished - Apr 2024

Bibliographical note

Copyright © 2024, Elsevier B.V. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

  • D2R
  • D1R
  • Arsenic
  • Cynara scolymus
  • AuNPs
  • Neurotoxicity

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