Basic implications on three pathways associated with SARS-CoV-2

Jong Hoon Lee; Consolato Sergi; Richard E. Kast; Badar A. Kanwar; Jean Bourbeau; Sangsuk Oh; Mun-Gi Sohn; Chul Joong Lee; Michael D. Coleman

doi:10.1016/j.bj.2024.100766

Basic implications on three pathways associated with SARS-CoV-2

Jong Hoon Lee, Consolato Sergi, Richard E. Kast, Badar A. Kanwar, Jean Bourbeau, Sangsuk Oh, Mun-Gi Sohn, Chul Joong Lee, Michael D. Coleman

Aston Pharmacy School

Research output: Contribution to journal › Article › peer-review

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts between the host and virus and govern induction, resulting in multiorgan impacts. Its pathophysiology involves the followings: 1) the angiotensin-converting enzyme (ACE2) and Toll-like receptor (TLR) pathways: 2) the neuropilin (NRP) pathway: 3) the spike protein pathway. Therefore, it is necessary to block the pathological course with modulating innate lymphoid cells against diverse corona variants in the future.

Original language	English
Article number	100766
Journal	Biomedical Journal
Early online date	14 Jul 2024
DOIs	https://doi.org/10.1016/j.bj.2024.100766
Publication status	E-pub ahead of print - 14 Jul 2024

Bibliographical note

Copyright © 2024 The Authors. Published by Elsevier B.V. on behalf of Chang Gung University. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Keywords

COVID-19
TLR
SARS-CoV-2
ACE2
Spike protein

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10.1016/j.bj.2024.100766Licence: CC BY-NC-ND 4.0

1-s2.0-S2319417024000696-main
Copyright © 2024 The Authors. Published by Elsevier B.V. on behalf of Chang Gung University. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Accepted author manuscript, 19.7 MBLicence: CC BY-NC-ND 4.0

Cite this

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title = "Basic implications on three pathways associated with SARS-CoV-2",

abstract = "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts between the host and virus and govern induction, resulting in multiorgan impacts. Its pathophysiology involves the followings: 1) the angiotensin-converting enzyme (ACE2) and Toll-like receptor (TLR) pathways: 2) the neuropilin (NRP) pathway: 3) the spike protein pathway. Therefore, it is necessary to block the pathological course with modulating innate lymphoid cells against diverse corona variants in the future. ",

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AU - Lee, Jong Hoon

AU - Sergi, Consolato

AU - Kast, Richard E.

AU - Kanwar, Badar A.

AU - Bourbeau, Jean

AU - Oh, Sangsuk

AU - Sohn, Mun-Gi

AU - Lee, Chul Joong

AU - Coleman, Michael D.

N1 - Copyright © 2024 The Authors. Published by Elsevier B.V. on behalf of Chang Gung University. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).

PY - 2024/7/14

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N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts between the host and virus and govern induction, resulting in multiorgan impacts. Its pathophysiology involves the followings: 1) the angiotensin-converting enzyme (ACE2) and Toll-like receptor (TLR) pathways: 2) the neuropilin (NRP) pathway: 3) the spike protein pathway. Therefore, it is necessary to block the pathological course with modulating innate lymphoid cells against diverse corona variants in the future.

AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts between the host and virus and govern induction, resulting in multiorgan impacts. Its pathophysiology involves the followings: 1) the angiotensin-converting enzyme (ACE2) and Toll-like receptor (TLR) pathways: 2) the neuropilin (NRP) pathway: 3) the spike protein pathway. Therefore, it is necessary to block the pathological course with modulating innate lymphoid cells against diverse corona variants in the future.

KW - COVID-19

KW - TLR

KW - SARS-CoV-2

KW - ACE2

KW - Spike protein

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M3 - Article

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SN - 2320-2890

JO - Biomedical Journal

JF - Biomedical Journal

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ER -

Basic implications on three pathways associated with SARS-CoV-2

Abstract

Bibliographical note

Keywords

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