Abstract
The density and spatial pattern of immunostained beta/A4 deposits and mature senile plaques (SP) stained by the Glees method were compared in Alzheimer's diseased brain. Thirty-seven percent of the variance in Glees SP density in a tissue could be explained by beta/A4. Both lesions were clustered with the beta/A4 clusters often larger than the Glees SP clusters. Beta/A4 and Glees SP cluster size were not correlated in a tissue. The size of Glees SP clusters was positively correlated with SP density but no correlation could be detected for beta/A4. Hence, the density and spatial pattern of beta/A4 deposits in most tissues did not predict the development of Glees SP.
| Original language | English |
|---|---|
| Pages (from-to) | 262-264 |
| Number of pages | 3 |
| Journal | NeuroReport |
| Volume | 3 |
| Issue number | 3 |
| Publication status | Published - Mar 1992 |
Keywords
- density pattern
- spatial pattern
- immunostained beta/A4 deposits
- mature senile plaques
- Alzheimer's disease
- brain