Brain mechanisms of altered consciousness in generalised seizures

Stefano Seri, Daniela Brazzo, Ngoc Thai-Goodson, Antonella Cerquiglini

Research output: Contribution to journalArticlepeer-review


In spite of the inherent difficulties in achieving a biologically meaningful definition of consciousness, recent neurophysiological studies are starting to provide some insight in fundamental mechanisms associated with impaired consciousness in neurological disorders. Generalised seizures are associated with disruption of the default state network, a functional network of discrete brain areas, which include the fronto-parietal cortices. Subcortical contribution through activation of thalamocortical structures, as well as striate nuclei are also crucial to produce impaired consciousness in generalised seizures.
Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalBehavioural Neurology
Issue number1
Early online date31 Mar 2011
Publication statusPublished - 2011

Bibliographical note

© 2011 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


  • consciousness
  • generalized epilepsy
  • functional imaging


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