Caffeine-induced synaptic potentiation in hippocampal CA2 neurons

Stephen B. Simons; Douglas A. Caruana; Meilan Zhao; Serena M. Dudek

doi:10.1038/nn.2962

Caffeine-induced synaptic potentiation in hippocampal CA2 neurons

Stephen B. Simons, Douglas A. Caruana, Meilan Zhao, Serena M. Dudek^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Caffeine enhances cognition, but even high non-physiological doses have modest effects on synapses. A 1 adenosine receptors (A 1 Rs) are antagonized by caffeine and are most highly enriched in hippocampal CA2, which has not been studied in this context. We found that physiological doses of caffeine in vivo or A 1 R antagonists in vitro induced robust, long-lasting potentiation of synaptic transmission in rat CA2 without affecting other regions of the hippocampus.

Original language	English
Pages (from-to)	23-25
Number of pages	3
Journal	Nature Neuroscience
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/nn.2962
Publication status	Published - 1 Jan 2012

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10.1038/nn.2962

Caffeine-induced synaptic potentiation in hippocampal CA2 neurons
Copyright © 2011, Springer Nature
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Caffeine-induced synaptic potentiation in hippocampal CA2 neurons

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