Calcitonin Gene-Related Peptide and Adrenomedullin Receptors

D. L. Hay*, A. C. Conner, D. R. Poyner

*Corresponding author for this work

Research output: Chapter in Book/Published conference outputChapter


Calcitonin gene-related peptide (CGRP) and adrenomedullin are related peptides, which are potent vasodilators. The CGRP and adrenomedullin receptors are unusual receptors, comprising a G-protein-coupled receptor (GPCR) with receptor activity-modifying proteins (RAMPs). The GPCR, the calcitonin receptor-like receptor (CLR), forms a CGRP receptor with RAMP1, whereas CLR with RAMP2 or RAMP3 forms two subtypes of adrenomedullin receptor. This article covers the pharmacology of these receptors, their distribution, and potential involvement in disease.

Original languageEnglish
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
Number of pages5
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
Publication statusPublished - 15 Feb 2013


  • Adrenomedullin
  • Calcitonin gene-related peptide
  • G-protein-coupled receptor
  • Receptor activity-modifying protein


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