Characterization of receptors by radiolabelled ligand binding techniques

I. L. Martin; M. Davies; S. M J Dunn

doi:10.1007/978-0-387-30401-4_10

Characterization of receptors by radiolabelled ligand binding techniques

I. L. Martin, M. Davies, S. M J Dunn

Aston Pharmacy School

Research output: Chapter in Book/Published conference output › Chapter

Abstract

Radiolabelled ligand binding studies remain one of the most widely used techniques in characterizing the biochemical and pharmacological properties of receptors. In this chapter, we provide an overview of radiolabelled ligand binding, discussing both theoretical and practical aspects of these experiments. Specific protocols that have been used in our laboratories to study the binding of radiolabelled ligands to two members of a ligand-gated ion channel family i.e., the nicotinic and GABA_A receptors are included.

Original language	English
Title of host publication	Handbook of Neurochemistry and Molecular Neurobiology: Practical Neurochemistry Methods
Publisher	Springer
Pages	257-274
Number of pages	18
ISBN (Print)	9780387303598
DOIs	https://doi.org/10.1007/978-0-387-30401-4_10
Publication status	Published - 1 Dec 2007

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10.1007/978-0-387-30401-4_10

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Characterization of receptors by radiolabelled ligand binding techniques

Abstract

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