Characterization of receptors by radiolabelled ligand binding techniques

I. L. Martin, M. Davies, S. M J Dunn

Research output: Chapter in Book/Published conference outputChapter


Radiolabelled ligand binding studies remain one of the most widely used techniques in characterizing the biochemical and pharmacological properties of receptors. In this chapter, we provide an overview of radiolabelled ligand binding, discussing both theoretical and practical aspects of these experiments. Specific protocols that have been used in our laboratories to study the binding of radiolabelled ligands to two members of a ligand-gated ion channel family i.e., the nicotinic and GABAA receptors are included.

Original languageEnglish
Title of host publicationHandbook of Neurochemistry and Molecular Neurobiology: Practical Neurochemistry Methods
Number of pages18
ISBN (Print)9780387303598
Publication statusPublished - 1 Dec 2007


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