TY - JOUR
T1 - Clustering of Pick bodies in patients with Pick's disease
AU - Armstrong, Richard A.
AU - Cairns, Nigel J.
AU - Lantos, Peter L.
PY - 1998/2/13
Y1 - 1998/2/13
N2 - Clustering of Pick bodies (PB) was studied in the frontal and temporal lobe in 10 cases of Pick's disease (PD). Pick bodies exhibited clustering in 47/50 (94%) brain areas analysed. In 20/50 (40%) brain areas, PB were present in a single large cluster ≤ 6400 μm in diameter, in 27/50 (54%) PB occurred in smaller clusters (200-3200 μm in diameter) which exhibited a regular periodicity relative to the tissue boundary, in 1/50 (2%) there was a regular distribution of individual PB and in 2/50 (4%), PB were randomly distributed. Mean cluster size of the PB was greater in the dentate gyrus compared with the inferior temporal gyrus and lateral occipitotemporal gyrus. Mean cluster size of PB in a brain region was positively correlated with the mean density of PB. Hence, PB exhibit essentially the same spatial patterns as senile plaques and neurofibrillary tangles in Alzheimer's disease (AD) and Lewy bodies in Dementia with Lewy bodies (DLB).
AB - Clustering of Pick bodies (PB) was studied in the frontal and temporal lobe in 10 cases of Pick's disease (PD). Pick bodies exhibited clustering in 47/50 (94%) brain areas analysed. In 20/50 (40%) brain areas, PB were present in a single large cluster ≤ 6400 μm in diameter, in 27/50 (54%) PB occurred in smaller clusters (200-3200 μm in diameter) which exhibited a regular periodicity relative to the tissue boundary, in 1/50 (2%) there was a regular distribution of individual PB and in 2/50 (4%), PB were randomly distributed. Mean cluster size of the PB was greater in the dentate gyrus compared with the inferior temporal gyrus and lateral occipitotemporal gyrus. Mean cluster size of PB in a brain region was positively correlated with the mean density of PB. Hence, PB exhibit essentially the same spatial patterns as senile plaques and neurofibrillary tangles in Alzheimer's disease (AD) and Lewy bodies in Dementia with Lewy bodies (DLB).
KW - Alzheimer's disease
KW - clustering
KW - frontal cortex
KW - Pick body
KW - Pick's disease
KW - temporal lobe
UR - http://www.scopus.com/inward/record.url?scp=0032512868&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/pii/S0304394098000524?via%3Dihub
U2 - 10.1016/S0304-3940(98)00052-4
DO - 10.1016/S0304-3940(98)00052-4
M3 - Article
C2 - 9533399
SN - 0304-3940
VL - 242
SP - 81
EP - 84
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -