Computer-aided biotechnology: from immuno-informatics to reverse vaccinology

Sandro Vivona, Jennifer L. Gardy, Srinivasan Ramachandran, Fiona S.L. Brinkman, G.P.S. Raghava, Darren R Flower, Francesco Filippini

Research output: Contribution to journalArticlepeer-review


Genome sequences from many organisms, including humans, have been completed, and high-throughput analyses have produced burgeoning volumes of 'omics' data. Bioinformatics is crucial for the management and analysis of such data and is increasingly used to accelerate progress in a wide variety of large-scale and object-specific functional analyses. Refined algorithms enable biotechnologists to follow 'computer-aided strategies' based on experiments driven by high-confidence predictions. In order to address compound problems, current efforts in immuno-informatics and reverse vaccinology are aimed at developing and tuning integrative approaches and user-friendly, automated bioinformatics environments. This will herald a move to 'computer-aided biotechnology': smart projects in which time-consuming and expensive large-scale experimental approaches are progressively replaced by prediction-driven investigations.
Original languageEnglish
Pages (from-to)190-200
Number of pages11
JournalTrends in Biotechnology
Issue number4
Early online date21 Feb 2008
Publication statusPublished - Apr 2008


  • allergy and immunology
  • animals
  • artificial intelligence
  • biomedical engineering
  • biotechnology
  • computer-aided design
  • database management systems
  • genetic databases
  • humans
  • immunity
  • active immunotherapy
  • user-computer interface


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