Copper complexes as a source of redox active MRI contrast agents

Lynsey Dunbar; Rebecca J. Sowden; Katherine D. Trotter; Michelle K. Taylor; David Smith; Alan R. Kennedy; John Reglinski; Corinne M. Spickett

doi:10.1007/s10534-015-9875-3

Copper complexes as a source of redox active MRI contrast agents

Lynsey Dunbar, Rebecca J. Sowden, Katherine D. Trotter, Michelle K. Taylor, David Smith, Alan R. Kennedy, John Reglinski^*, Corinne M. Spickett

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.

Original language	English
Pages (from-to)	903-912
Number of pages	10
Journal	BioMetals
Volume	28
Issue number	5
Early online date	9 Aug 2015
DOIs	https://doi.org/10.1007/s10534-015-9875-3
Publication status	Published - 2015

Bibliographical note

The final publication is available at Springer via http://dx.doi.org/10.1007/s10534-015-9875-3

Funding: BBSRC (BBS/B/01553).

Electronic supplementary material (doi: 10.1007/s10534-015-9875-3).

Keywords

copper macrocycles
oxidation–reduction
Redox sensitive contrast agent
imaging
inflammation

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10.1007/s10534-015-9875-3

Copper complexes as a source of redox active MRI contrast agents
The final publication is available at Springer via http://dx.doi.org/10.1007/s10534-015-9875-3
Accepted author manuscript, 464 KB

http://link.springer.com/article/10.1007%2Fs10534-015-9875-3

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title = "Copper complexes as a source of redox active MRI contrast agents",

abstract = "The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.",

keywords = "copper macrocycles, oxidation–reduction, Redox sensitive contrast agent, imaging, inflammation",

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note = "The final publication is available at Springer via http://dx.doi.org/10.1007/s10534-015-9875-3 Funding: BBSRC (BBS/B/01553). Electronic supplementary material (doi: 10.1007/s10534-015-9875-3).",

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doi = "10.1007/s10534-015-9875-3",

language = "English",

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AU - Dunbar, Lynsey

AU - Sowden, Rebecca J.

AU - Trotter, Katherine D.

AU - Taylor, Michelle K.

AU - Smith, David

AU - Kennedy, Alan R.

AU - Reglinski, John

AU - Spickett, Corinne M.

N1 - The final publication is available at Springer via http://dx.doi.org/10.1007/s10534-015-9875-3 Funding: BBSRC (BBS/B/01553). Electronic supplementary material (doi: 10.1007/s10534-015-9875-3).

PY - 2015

Y1 - 2015

N2 - The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.

AB - The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.

KW - copper macrocycles

KW - oxidation–reduction

KW - Redox sensitive contrast agent

KW - imaging

KW - inflammation

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SP - 903

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JO - BioMetals

JF - BioMetals

IS - 5

ER -

Copper complexes as a source of redox active MRI contrast agents

Abstract

Bibliographical note

Keywords

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