Corpus callosum size and shape alterations in adolescent inhalant users.

Michael Takagi, Dan I. Lubman, Mark Walterfang, Sarah Barton, David Reutens, Amanda Wood, Murat Yücel

Research output: Contribution to journalArticlepeer-review


Inhalants, frequently abused during adolescence, are neurotoxic to white matter. We investigated the impact of inhalant misuse on the morphology of the corpus callosum (CC), the largest white matter bundle in the brain, in an adolescent sample of inhalant users [n = 14; mean age = 17.3; standard deviation (SD) = 1.7], cannabis users (n = 11; mean age = 19.7; SD = 1.7) and community controls (n = 9; mean age = 19.5; SD = 2.6). We identified significant morphological differences in the CC among inhalant users compared with community controls. There were no morphological differences between inhalant and cannabis users. Our findings may represent the early stages of neurobiological damage associated with chronic inhalant misuse.
Original languageEnglish
Pages (from-to)851–854
Number of pages4
JournalAddiction Biology
Issue number5
Publication statusPublished - Sept 2011


  • adolescents
  • cannabis
  • corpus callosum
  • diffusion tensor imaging
  • inhalants
  • neuroimaging


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