Designing immunogenic peptides

Darren R. Flower*

*Corresponding author for this work

Research output: Contribution to journalLetter, comment/opinion or interviewpeer-review


Peptides fulfill many roles in immunology, yet none are more important than their role as immunogenic epitopes driving the adaptive immune response, our ultimate bulwark against infectious disease. Peptide epitopes are mediated primarily by their interaction with major histocompatibility complexes (T-cell epitopes) and antibodies (B-cell epitopes). As pathogen genomes continue to be revealed, both experimental and computational epitope mapping are becoming crucial tools in vaccine discovery1,2. Immunoinformatics offers many tools, techniques and approaches for in silico epitope characterization, which is capable of greatly accelerating epitope design.

Original languageEnglish
Pages (from-to)749-753
Number of pages5
JournalNature Chemical Biology
Issue number12
Early online date14 Nov 2013
Publication statusPublished - Dec 2013


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