Development of a physiologically-based pharmacokinetic model of the rat central nervous system

Keyphrases

• Central Nervous System 100%
• Physiologically-based Pharmacokinetic Model 100%
• Cerebrospinal Fluid 100%
• Pharmacokinetics 33%
• In Vitro Permeation 33%
• Drug Disposition 33%
• Brain Fluids 33%
• Kpuu 33%
• Simultaneous Analysis 16%
• 4-fold 16%
• Drug Transporters 16%
• Choroidal 16%
• Blood-brain Barrier 16%
• Physiological Barriers 16%
• Mdr1a 16%
• Simultaneous Simulation 16%
• Fluid Compartments 16%
• Biophase 16%
• Drug Physicochemical Properties 16%
• Blood-cerebrospinal Fluid Barrier 16%
• Partition Ratio 16%
• Brain Interstitial Fluid 16%
• Development Pathways 16%
• Plasma Fluid 16%
• Unbound Fraction 16%
• Central Nervous System Drugs 16%

Neuroscience

• Central Nervous System 100%
• Pharmacokinetics 100%
• Blood Plasma 66%
• In Vitro 33%
• In Vivo 16%
• Carrier Protein 16%
• Blood Brain Barrier 16%
• Blood Cerebrospinal Fluid Barrier 16%
• Interstitial Fluid 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Pharmacokinetics 100%
• Carrier Protein 25%
• Central Nervous System Drug 25%
• Blood-Brain Barrier 25%