Diagnosis and management of hereditary renal cell cancer

Fred H. Menko*, Eamonn R. Maher

*Corresponding author for this work

Research output: Chapter in Book/Published conference outputChapter (peer-reviewed)peer-review


Renal cell cancer (RCC) is the common denominator for a heterogeneous group of diseases. The subclassification of these tumours is based on histological type and molecular pathogenesis. Insight into molecular pathogenesis has led to the development of targeted systemic therapies. Genetic susceptibility is the principal cause of RCC in about 2–4 % of cases. Hereditary RCC is the umbrella term for about a dozen different conditions, the most frequent of which is von Hippel– Lindau disease. Here, we describe the main hereditary RCC syndromes, consider criteria for referral of RCC patients for clinical genetic assessment and discuss management options for patients with hereditary RCC and their at-risk relatives.

Original languageEnglish
Title of host publicationRare Hereditary Cancers
EditorsG. Pichert, C. Jacobs
Number of pages20
ISBN (Electronic)978-3-319-29998-3
ISBN (Print)978-3-319-29996-9
Publication statusPublished - 14 Apr 2016

Publication series

NameRecent Results in Cancer Research
ISSN (Print)0080-0015


  • Hereditary
  • Management
  • Molecular pathogenesis
  • Renal cell cancer


Dive into the research topics of 'Diagnosis and management of hereditary renal cell cancer'. Together they form a unique fingerprint.

Cite this