Disinfection of surgical materials using photo-activated tolonium chloride

Gareth A. Thomson; R. Mackay; Mark S. Pridham; Y.L. Liu

doi:10.1007/978-3-642-03885-3_38

Disinfection of surgical materials using photo-activated tolonium chloride

Gareth A. Thomson, R. Mackay, Mark S. Pridham, Y.L. Liu

Research output: Chapter in Book/Published conference output › Conference publication

Abstract

Photo-activated disinfection is a technique which has recently become available for use in disinfection in dentistry. This technique makes use of the dye toluidine blue O coupled to a low powered laser to generate singlet oxygen which kills the bacteria without harming the patient. In this paper trials were performed to try to investigate the possibility of the technique for use in other medical applications, particularly related to implants, and orthopedic fixtures. In the trials, samples of stainless steel and polymethylmethacrylate (PMMA) were exposed to Staphylococcus Aureus and Staphylococcus Epidermis bacteria before being treated with a variety of irradiation exposures. Results found that if laser exposure energy exceeded 4.25 J/cm² then a log reduction of 4 times CFU/cm² might be expected. Results were similar for both the highly reflective stainless steel and transparent PMMA. Trials were also performed using light emitting diode technology and while these results were less effective, it is felt that the rapid rate of developments in this technology could lead to a cost effective route to rolling photo-activated disinfection out to many more medical applications.

Original language	English
Title of host publication	World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany
Subtitle of host publication	diagnostic and therapeutic instrumentation, clinical engineering
Editors	Olaf Dössel, Wolfgang C. Schlegel
Place of Publication	Berlin (DE)
Publisher	Springer
Pages	133-136
Number of pages	4
ISBN (Electronic)	978-3-642-03900-3
ISBN (Print)	978-3-642-03899-0
DOIs	https://doi.org/10.1007/978-3-642-03885-3_38
Publication status	Published - 1 Dec 2009
Event	World Congress on Medical Physics and Biomedical Engineering - Munich, Germany Duration: 7 Sept 2009 → 12 Sept 2009

Publication series

Name	IFMBE Proceedings
Publisher	Springer
Number	10
Volume	25
ISSN (Print)	1680-0737
ISSN (Electronic)	1433-9277

Congress

Congress	World Congress on Medical Physics and Biomedical Engineering
Country/Territory	Germany
City	Munich
Period	7/09/09 → 12/09/09
Other	Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics

Keywords

bacteria
disinfection
laser
staphylococcus Aureus
staphylococcus Epidermis

Access to Document

10.1007/978-3-642-03885-3_38

Cite this

Thomson, G. A., Mackay, R., Pridham, M. S., & Liu, Y. L. (2009). Disinfection of surgical materials using photo-activated tolonium chloride. In O. Dössel, & W. C. Schlegel (Eds.), World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany: diagnostic and therapeutic instrumentation, clinical engineering (pp. 133-136). (IFMBE Proceedings; Vol. 25, No. 10). Springer. https://doi.org/10.1007/978-3-642-03885-3_38

Thomson, Gareth A. ; Mackay, R. ; Pridham, Mark S. et al. / Disinfection of surgical materials using photo-activated tolonium chloride. World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany: diagnostic and therapeutic instrumentation, clinical engineering. editor / Olaf Dössel ; Wolfgang C. Schlegel. Berlin (DE) : Springer, 2009. pp. 133-136 (IFMBE Proceedings; 10).

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title = "Disinfection of surgical materials using photo-activated tolonium chloride",

abstract = "Photo-activated disinfection is a technique which has recently become available for use in disinfection in dentistry. This technique makes use of the dye toluidine blue O coupled to a low powered laser to generate singlet oxygen which kills the bacteria without harming the patient. In this paper trials were performed to try to investigate the possibility of the technique for use in other medical applications, particularly related to implants, and orthopedic fixtures. In the trials, samples of stainless steel and polymethylmethacrylate (PMMA) were exposed to Staphylococcus Aureus and Staphylococcus Epidermis bacteria before being treated with a variety of irradiation exposures. Results found that if laser exposure energy exceeded 4.25 J/cm2 then a log reduction of 4 times CFU/cm2 might be expected. Results were similar for both the highly reflective stainless steel and transparent PMMA. Trials were also performed using light emitting diode technology and while these results were less effective, it is felt that the rapid rate of developments in this technology could lead to a cost effective route to rolling photo-activated disinfection out to many more medical applications.",

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Thomson, GA, Mackay, R, Pridham, MS & Liu, YL 2009, Disinfection of surgical materials using photo-activated tolonium chloride. in O Dössel & WC Schlegel (eds), World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany: diagnostic and therapeutic instrumentation, clinical engineering. IFMBE Proceedings, no. 10, vol. 25, Springer, Berlin (DE), pp. 133-136, World Congress on Medical Physics and Biomedical Engineering, Munich, Germany, 7/09/09. https://doi.org/10.1007/978-3-642-03885-3_38

Disinfection of surgical materials using photo-activated tolonium chloride. / Thomson, Gareth A.; Mackay, R.; Pridham, Mark S. et al.
World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany: diagnostic and therapeutic instrumentation, clinical engineering. ed. / Olaf Dössel; Wolfgang C. Schlegel. Berlin (DE): Springer, 2009. p. 133-136 (IFMBE Proceedings; Vol. 25, No. 10).

Research output: Chapter in Book/Published conference output › Conference publication

TY - GEN

T1 - Disinfection of surgical materials using photo-activated tolonium chloride

AU - Thomson, Gareth A.

AU - Mackay, R.

AU - Pridham, Mark S.

AU - Liu, Y.L.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Photo-activated disinfection is a technique which has recently become available for use in disinfection in dentistry. This technique makes use of the dye toluidine blue O coupled to a low powered laser to generate singlet oxygen which kills the bacteria without harming the patient. In this paper trials were performed to try to investigate the possibility of the technique for use in other medical applications, particularly related to implants, and orthopedic fixtures. In the trials, samples of stainless steel and polymethylmethacrylate (PMMA) were exposed to Staphylococcus Aureus and Staphylococcus Epidermis bacteria before being treated with a variety of irradiation exposures. Results found that if laser exposure energy exceeded 4.25 J/cm2 then a log reduction of 4 times CFU/cm2 might be expected. Results were similar for both the highly reflective stainless steel and transparent PMMA. Trials were also performed using light emitting diode technology and while these results were less effective, it is felt that the rapid rate of developments in this technology could lead to a cost effective route to rolling photo-activated disinfection out to many more medical applications.

AB - Photo-activated disinfection is a technique which has recently become available for use in disinfection in dentistry. This technique makes use of the dye toluidine blue O coupled to a low powered laser to generate singlet oxygen which kills the bacteria without harming the patient. In this paper trials were performed to try to investigate the possibility of the technique for use in other medical applications, particularly related to implants, and orthopedic fixtures. In the trials, samples of stainless steel and polymethylmethacrylate (PMMA) were exposed to Staphylococcus Aureus and Staphylococcus Epidermis bacteria before being treated with a variety of irradiation exposures. Results found that if laser exposure energy exceeded 4.25 J/cm2 then a log reduction of 4 times CFU/cm2 might be expected. Results were similar for both the highly reflective stainless steel and transparent PMMA. Trials were also performed using light emitting diode technology and while these results were less effective, it is felt that the rapid rate of developments in this technology could lead to a cost effective route to rolling photo-activated disinfection out to many more medical applications.

KW - bacteria

KW - disinfection

KW - laser

KW - staphylococcus Aureus

KW - staphylococcus Epidermis

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SN - 978-3-642-03899-0

T3 - IFMBE Proceedings

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EP - 136

BT - World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany

A2 - Dössel, Olaf

A2 - Schlegel, Wolfgang C.

PB - Springer

CY - Berlin (DE)

T2 - World Congress on Medical Physics and Biomedical Engineering

Y2 - 7 September 2009 through 12 September 2009

ER -

Thomson GA, Mackay R, Pridham MS, Liu YL. Disinfection of surgical materials using photo-activated tolonium chloride. In Dössel O, Schlegel WC, editors, World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany: diagnostic and therapeutic instrumentation, clinical engineering. Berlin (DE): Springer. 2009. p. 133-136. (IFMBE Proceedings; 10). doi: 10.1007/978-3-642-03885-3_38

Disinfection of surgical materials using photo-activated tolonium chloride

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Keywords

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