Abstract
Single cell recordings in monkeys support the notion that the lateral prefrontal cortex (PFC) controls reactivation of visual working memory representations when rehearsal is disrupted. In contrast, recent fMRI findings yielded a double dissociation for PFC and the medial temporal lobe (MTL) in a letter working memory task. PFC was engaged in interference protection during reactivation while MTL was prominently involved in the retrieval of the letter representations. We present event-related potential data (ERP) that support PFC involvement in the top-down control of reactivation during a visual working memory task with endogenously triggered recovery after visual interference. A differentiating view is proposed for the role of PFC in working memory with respect to endogenous/exogenous control and to stimulus type. General implications for binding and retention mechanisms are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 1075-1087 |
| Number of pages | 13 |
| Journal | Cerebral Cortex |
| Volume | 15 |
| Issue number | 7 |
| Early online date | 24 Nov 2004 |
| DOIs | |
| Publication status | Published - Jul 2005 |
Bibliographical note
This is a pre-copyedited, author-produced PDF of an article accepted for publication in Cerebral cortex following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: http://cercor.oxfordjournals.org/content/15/7/1075.abstractKeywords
- prefrontal cortex
- working memory
- temporal lobe
- endogenously triggered recovery
- exogenous control
- endogenous control