Dynamic surface activity of biological fluids, ophthalmic solutions and nanostructures

Steve Tonge; Vincent Rebeix; Richard Young; Brian Tighe

doi:10.1007/978-1-4615-0717-8_83

Dynamic surface activity of biological fluids, ophthalmic solutions and nanostructures

Steve Tonge^*, Vincent Rebeix, Richard Young, Brian Tighe

^*Corresponding author for this work

Research output: Chapter in Book/Published conference output › Chapter (peer-reviewed) › peer-review

Abstract

Various fluids including tears, pulmonary surfactant and synovial fluid lubricate the surfaces of the body. All have a similar function in that they act as boundary lubricants to prevent focal adhesions and minimize transmittance of shear forces.1 These fluids also exhibit some remarkable similarities in composition in that they all contain a phospholipid, dipalmitoylphosphatidylcholine, in combination with an amphipathic apoprotein or lipocalin to organize the lipid into lamellar sheets. The challenge in producing replacements for these fluids in treating lubricity deficiency diseases such as dry eye, respiratory distress syndrome and arthritis is not in replacing the phospholipid, which is readily available in synthetic form, but in replacing the apoprotein component.

Original language	English
Title of host publication	Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3
Editors	D.A. Sullivan, M.E. Stern, K. Tsubota, D.A. Dartt, R.M. Sullivan, B.B. Bromberg
Place of Publication	Boston, MA
Pages	593-599
Number of pages	7
Volume	506
ISBN (Electronic)	978-1-4615-0717-8
DOIs	https://doi.org/10.1007/978-1-4615-0717-8_83
Publication status	Published - 2002

Publication series

Name	Advances in Experimental Medicine and Biology
Publisher	Springer
ISSN (Print)	0065-2598

Keywords

ocular surface
pepsin digestion
Ocular surface disease
Keratoconjunctivitis Sicca
Lacrimal Duct

Access to Document

10.1007/978-1-4615-0717-8_83

Cite this

Tonge, S., Rebeix, V., Young, R., & Tighe, B. (2002). Dynamic surface activity of biological fluids, ophthalmic solutions and nanostructures. In D. A. Sullivan, M. E. Stern, K. Tsubota, D. A. Dartt, R. M. Sullivan, & B. B. Bromberg (Eds.), Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3 (Vol. 506, pp. 593-599). (Advances in Experimental Medicine and Biology).. https://doi.org/10.1007/978-1-4615-0717-8_83

Tonge, Steve ; Rebeix, Vincent ; Young, Richard et al. / Dynamic surface activity of biological fluids, ophthalmic solutions and nanostructures. Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. editor / D.A. Sullivan ; M.E. Stern ; K. Tsubota ; D.A. Dartt ; R.M. Sullivan ; B.B. Bromberg. Vol. 506 Boston, MA, 2002. pp. 593-599 (Advances in Experimental Medicine and Biology).

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abstract = "Various fluids including tears, pulmonary surfactant and synovial fluid lubricate the surfaces of the body. All have a similar function in that they act as boundary lubricants to prevent focal adhesions and minimize transmittance of shear forces.1 These fluids also exhibit some remarkable similarities in composition in that they all contain a phospholipid, dipalmitoylphosphatidylcholine, in combination with an amphipathic apoprotein or lipocalin to organize the lipid into lamellar sheets. The challenge in producing replacements for these fluids in treating lubricity deficiency diseases such as dry eye, respiratory distress syndrome and arthritis is not in replacing the phospholipid, which is readily available in synthetic form, but in replacing the apoprotein component.",

keywords = "ocular surface, pepsin digestion, Ocular surface disease, Keratoconjunctivitis Sicca, Lacrimal Duct",

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Tonge, S, Rebeix, V, Young, R & Tighe, B 2002, Dynamic surface activity of biological fluids, ophthalmic solutions and nanostructures. in DA Sullivan, ME Stern, K Tsubota, DA Dartt, RM Sullivan & BB Bromberg (eds), Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. vol. 506, Advances in Experimental Medicine and Biology, Boston, MA, pp. 593-599. https://doi.org/10.1007/978-1-4615-0717-8_83

Dynamic surface activity of biological fluids, ophthalmic solutions and nanostructures. / Tonge, Steve; Rebeix, Vincent; Young, Richard et al.
Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. ed. / D.A. Sullivan; M.E. Stern; K. Tsubota; D.A. Dartt; R.M. Sullivan; B.B. Bromberg. Vol. 506 Boston, MA, 2002. p. 593-599 (Advances in Experimental Medicine and Biology).

Research output: Chapter in Book/Published conference output › Chapter (peer-reviewed) › peer-review

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T1 - Dynamic surface activity of biological fluids, ophthalmic solutions and nanostructures

AU - Tonge, Steve

AU - Rebeix, Vincent

AU - Young, Richard

AU - Tighe, Brian

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N2 - Various fluids including tears, pulmonary surfactant and synovial fluid lubricate the surfaces of the body. All have a similar function in that they act as boundary lubricants to prevent focal adhesions and minimize transmittance of shear forces.1 These fluids also exhibit some remarkable similarities in composition in that they all contain a phospholipid, dipalmitoylphosphatidylcholine, in combination with an amphipathic apoprotein or lipocalin to organize the lipid into lamellar sheets. The challenge in producing replacements for these fluids in treating lubricity deficiency diseases such as dry eye, respiratory distress syndrome and arthritis is not in replacing the phospholipid, which is readily available in synthetic form, but in replacing the apoprotein component.

AB - Various fluids including tears, pulmonary surfactant and synovial fluid lubricate the surfaces of the body. All have a similar function in that they act as boundary lubricants to prevent focal adhesions and minimize transmittance of shear forces.1 These fluids also exhibit some remarkable similarities in composition in that they all contain a phospholipid, dipalmitoylphosphatidylcholine, in combination with an amphipathic apoprotein or lipocalin to organize the lipid into lamellar sheets. The challenge in producing replacements for these fluids in treating lubricity deficiency diseases such as dry eye, respiratory distress syndrome and arthritis is not in replacing the phospholipid, which is readily available in synthetic form, but in replacing the apoprotein component.

KW - ocular surface

KW - pepsin digestion

KW - Ocular surface disease

KW - Keratoconjunctivitis Sicca

KW - Lacrimal Duct

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Tonge S, Rebeix V, Young R, Tighe B. Dynamic surface activity of biological fluids, ophthalmic solutions and nanostructures. In Sullivan DA, Stern ME, Tsubota K, Dartt DA, Sullivan RM, Bromberg BB, editors, Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Vol. 506. Boston, MA. 2002. p. 593-599. (Advances in Experimental Medicine and Biology). doi: 10.1007/978-1-4615-0717-8_83

Dynamic surface activity of biological fluids, ophthalmic solutions and nanostructures

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