Early warnings of heart rate deterioration

Vânia G. Almeida, Ian T. Nabney

Research output: Chapter in Book/Published conference outputConference publication


Hospitals can experience difficulty in detecting and responding to early signs of patient deterioration leading to late intensive care referrals, excess mortality and morbidity, and increased hospital costs. Our study aims to explore potential indicators of physiological deterioration by the analysis of vital-signs. The dataset used comprises heart rate (HR) measurements from MIMIC II waveform database, taken from six patients admitted to the Intensive Care Unit (ICU) and diagnosed with severe sepsis. Different indicators were considered: 1) generic early warning indicators used in ecosystems analysis (autocorrelation at-1-lag (ACF1), standard deviation (SD), skewness, kurtosis and heteroskedasticity) and 2) entropy analysis (kernel entropy and multi scale entropy). Our preliminary findings suggest that when a critical transition is approaching, the equilibrium state changes what is visible in the ACF1 and SD values, but also by the analysis of the entropy. Entropy allows to characterize the complexity of the time series during the hospital stay and can be used as an indicator of regime shifts in a patient’s condition. One of the main problems is its dependency of the scale used. Our results demonstrate that different entropy scales should be used depending of the level of entropy verified.
Original languageEnglish
Title of host publication2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
Number of pages4
ISBN (Print)978-1-4577-0220-4
Publication statusPublished - 13 Oct 2016
Event38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Orlando, United States
Duration: 16 Aug 201620 Aug 2016

Publication series

ISSN (Electronic)1558-4615


Conference38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Abbreviated titleEMBC 2016
Country/TerritoryUnited States

Bibliographical note

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