Effect of a liposomal spray on the pre-ocular tear film

Jennifer P. Craig, Christine Purslow, Paul J. Murphy, James S W Wolffsohn

Research output: Contribution to journalArticlepeer-review


Purpose: With the potential to address evaporative dry eye, a novel spray has been developed in which phospholipid liposomes are delivered to the tear film via the surface of the closed eyelid. This study evaluated the short-term effects of liposomal spray application on the lipid and stability characteristics of the pre-ocular tear film in normal eyes.
Methods: Twenty-two subjects (12M, 10F) aged 35.1 ± 7.1 years participated in this prospective, randomised, double-masked investigation in which the liposomal spray was applied to one eye, and an equal volume of saline spray (control) applied to the contralateral eye. Lipid layer grade (LLG), non-invasive tear film stability (NIBUT) and tear meniscus height (TMH) were evaluated at baseline, and at 30, 60, 90 and 135 minutes post-application. Subjective reports of comfort were also compared.
Results: Treated and control eyes were not significantly different at baseline (p>0.05). Post-application, LLG increased significantly, at 30 and 60 minutes, only in the treated eyes (p=0.005). NIBUT also increased significantly in the treated eyes only (p<0.001), at 30, 60 and 90 minutes. TMH did not alter significantly (p>0.05). Comfort improved relative to baseline in 46% of treated and 18% of control eyes, respectively, at 30 minutes post-application. Of those expressing a preference in comfort between the eyes, 68% preferred the liposomal spray.
Conclusions: Consistent with subjective reports of improved comfort, statistically and clinically significant improvements in lipid layer thickness and tear film stability are observed in normal eyes for at least an hour after a single application of a phospholipid liposomal spray.
Original languageEnglish
Pages (from-to)83-87
Number of pages5
JournalContact Lens and Anterior Eye
Issue number2
Early online date21 Jan 2010
Publication statusPublished - Apr 2010

Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in Contact lens and anterior eye. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Craig, JP, Purslow, C, Murphy, PJ & Wolffsohn, JSW, 'Effect of a liposomal spray on the pre-ocular tear film', Contact lens and anterior eye, vol 33, no. 2 (2010) DOI http://dx.doi.org/10.1016/j.clae.2009.12.007


  • adult
  • aerosols
  • dry eye syndromes
  • female
  • humans
  • liposomes
  • male
  • ophthalmic solutions
  • tears
  • treatment outcome


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