Effect of catechol derivatives on cell growth and lipoxygenase activity

Julie Simpson, Rebecca Forrester, Michael J. Tisdale, David C. Billington, Daniel L. Rathbone*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC 5010 -6-10 -7 M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC 50 ∼1 μM). © 2003 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)2435-2439
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number15
Publication statusPublished - 4 Aug 2003


  • salicylic acid
  • lipoxygenase inhibitors
  • phenolic dihydroxy moiety
  • murine colonic tumour cells
  • inhibitors
  • catechols


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