TY - JOUR
T1 - Effect of catechol derivatives on cell growth and lipoxygenase activity
AU - Simpson, Julie
AU - Forrester, Rebecca
AU - Tisdale, Michael J.
AU - Billington, David C.
AU - Rathbone, Daniel L.
PY - 2003/8/4
Y1 - 2003/8/4
N2 - Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC
5010
-6-10
-7 M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC
50 ∼1 μM). © 2003 Elsevier Ltd. All rights reserved.
AB - Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC
5010
-6-10
-7 M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC
50 ∼1 μM). © 2003 Elsevier Ltd. All rights reserved.
KW - salicylic acid
KW - lipoxygenase inhibitors
KW - phenolic dihydroxy moiety
KW - murine colonic tumour cells
KW - inhibitors
KW - catechols
UR - http://www.scopus.com/inward/record.url?scp=0037972031&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(03)00528-6
DO - 10.1016/S0960-894X(03)00528-6
M3 - Article
C2 - 12852938
SN - 0960-894X
VL - 13
SP - 2435
EP - 2439
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 15
ER -