Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load

Stefanie Hassel; Jorge R.C. Almeida; Natalie Kerr; Sharon A. Nau; Cecile D. Ladouceur; Kate Fissell; David J. Kupfer; Mary L. Phillips

doi:10.1111/j.1399-5618.2008.00641.x

Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load

Stefanie Hassel, Jorge R.C. Almeida, Natalie Kerr, Sharon A. Nau, Cecile D. Ladouceur, Kate Fissell, David J. Kupfer, Mary L. Phillips

Research output: Contribution to journal › Article › peer-review

Abstract

To examine abnormal patterns of frontal cortical-subcortical activity in response to emotional stimuli in euthymic individuals with bipolar disorder type I in order to identify trait-like, pathophysiologic mechanisms of the disorder. We examined potential confounding effects of total psychotropic medication load and illness variables upon neural abnormalities.

Original language	English
Pages (from-to)	916-927
Number of pages	12
Journal	Bipolar Disorders
Volume	10
Issue number	8
Early online date	18 Nov 2008
DOIs	https://doi.org/10.1111/j.1399-5618.2008.00641.x
Publication status	Published - Dec 2008

Keywords

magnetic resonance imaging
emotions
computer-assisted image interpretation
arousal
bipolar disorder
humans international agencies receptors
psychotropic drugs
corpus striatum
prefrontal cortex
cerebral dominance
limbic system
nerve net
comorbidity
cerebral cortex
combination drug therapy
oxygen
facial expression
brain mapping
visual pattern recognition
adult
middle aged
amygdala
male
female
emotion processing
functional MRI

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10.1111/j.1399-5618.2008.00641.x

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Hassel, S., Almeida, J. R. C., Kerr, N., Nau, S. A., Ladouceur, C. D., Fissell, K., Kupfer, D. J., & Phillips, M. L. (2008). Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load. Bipolar Disorders, 10(8), 916-927. https://doi.org/10.1111/j.1399-5618.2008.00641.x

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title = "Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load",

abstract = "To examine abnormal patterns of frontal cortical-subcortical activity in response to emotional stimuli in euthymic individuals with bipolar disorder type I in order to identify trait-like, pathophysiologic mechanisms of the disorder. We examined potential confounding effects of total psychotropic medication load and illness variables upon neural abnormalities.",

keywords = "magnetic resonance imaging, emotions, computer-assisted image interpretation, arousal, bipolar disorder, humans international agencies receptors, psychotropic drugs, corpus striatum, prefrontal cortex, cerebral dominance, limbic system, nerve net, comorbidity, cerebral cortex, combination drug therapy, oxygen, facial expression, brain mapping, visual pattern recognition, adult, middle aged, amygdala, male, female, emotion processing, functional MRI",

author = "Stefanie Hassel and Almeida, {Jorge R.C.} and Natalie Kerr and Nau, {Sharon A.} and Ladouceur, {Cecile D.} and Kate Fissell and Kupfer, {David J.} and Phillips, {Mary L.}",

year = "2008",

month = dec,

doi = "10.1111/j.1399-5618.2008.00641.x",

language = "English",

volume = "10",

pages = "916--927",

journal = "Bipolar Disorders",

issn = "1399-5618",

publisher = "Blackwell",

number = "8",

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Hassel, S, Almeida, JRC, Kerr, N, Nau, SA, Ladouceur, CD, Fissell, K, Kupfer, DJ & Phillips, ML 2008, 'Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load', Bipolar Disorders, vol. 10, no. 8, pp. 916-927. https://doi.org/10.1111/j.1399-5618.2008.00641.x

Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load. / Hassel, Stefanie; Almeida, Jorge R.C.; Kerr, Natalie et al.
In: Bipolar Disorders, Vol. 10, No. 8, 12.2008, p. 916-927.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder

T2 - no associations with psychotropic medication load

AU - Hassel, Stefanie

AU - Almeida, Jorge R.C.

AU - Kerr, Natalie

AU - Nau, Sharon A.

AU - Ladouceur, Cecile D.

AU - Fissell, Kate

AU - Kupfer, David J.

AU - Phillips, Mary L.

PY - 2008/12

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KW - emotions

KW - computer-assisted image interpretation

KW - arousal

KW - bipolar disorder

KW - humans international agencies receptors

KW - psychotropic drugs

KW - corpus striatum

KW - prefrontal cortex

KW - cerebral dominance

KW - limbic system

KW - nerve net

KW - comorbidity

KW - cerebral cortex

KW - combination drug therapy

KW - oxygen

KW - facial expression

KW - brain mapping

KW - visual pattern recognition

KW - adult

KW - middle aged

KW - amygdala

KW - male

KW - female

KW - emotion processing

KW - functional MRI

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DO - 10.1111/j.1399-5618.2008.00641.x

M3 - Article

C2 - 19594507

SN - 1399-5618

VL - 10

SP - 916

EP - 927

JO - Bipolar Disorders

JF - Bipolar Disorders

IS - 8

ER -

Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load

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Keywords

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