Endometallofullerenes and their derivatives: Synthesis, physicochemical properties, and perspective application in biomedicine

Vasiliy T. Lebedev, Nikolay A. Charykov, Olga S. Shemchuk, Igor V. Murin, Dmitry A. Nerukh, Andrey V. Petrov, Dmitriy N. Maystrenko, Oleg E. Molchanov, Vladimir V. Sharoyko*, Konstantin N. Semenov

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


We review all aspects of the synthesis, properties, and applications of endometallofullerenes (EMF) over the last 20 years. EMF represent a new class of nanosized objects with specific physicochemical properties defined by the encapsulation of individual atoms and small molecules with significant potential of practical applications in biology and medicine. One such application is an EMF based anticancer drug capable of activating antitumour immune response, inhibition of the tumour development, and inhibition of angiogenesis and metastasis. Another, separate application direction is the use of EMF as contrast agents.

Original languageEnglish
Article number113133
Number of pages16
JournalColloids and Surfaces B: Biointerfaces
Early online date18 Jan 2023
Publication statusPublished - Feb 2023

Bibliographical note

Funding Information:
This research was funded by the Russian Foundation for Basic Researches , Grant number 18-29-19008 , partially by Kurchatov Institute according to the state assignment for the theme “2.4. Carbon based nanomaterials” and by Governor Fellowship of Leningrad District personally for V.T. Lebedev (2022–2023) . The work was carried out with the financial support of the Ministry of Health of the Russian Federation “Development of molecular design and creation of drugs based on conjugates of carbon nanostructures, targeted delivery vectors and cytotoxic agents for inactivation of tumor stem cells and components of the tumor microenvironment”.

Publisher Copyright:
Copyright © 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. The Version of Record can be found here: https://doi.org/10.1016/j.colsurfb.2023.113133


  • Endometallofullerenes
  • Functionalization
  • MRI-diagnostic
  • Physicochemical properties


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