Facile synthesis of polymer-peptide conjugates via direct amino acid coupling chemistry

Gwen F. Chimonides, Arun A. Sohdi, Mohammad R. Khaleghi, Claire R. Hurley, Dave J. Adams, Paul D. Topham*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Polymer-peptide conjugates (also known as biohy-brids) are attracting considerable attention as injectable materials owing to the self-assembling behavior of the peptide and the ability to control the material properties using the polymer component. To this end, a simple method for preparing poly(ethylene oxide)-oligophenylalanine polymer-peptide conjugates (mPEOm-F n-OEt) using isobutylchloroformate as the activating reagent has been identified and developed. The synthetic approach reported employs an industrially viable route to produce conjugates with high yield and purity. Moreover, the approach allows judicious selection of the precursor building blocks to produce libraries of polymer-peptide conjugates with complete control over the molecular composition. Control over the molecular make-up of the conjugates allows fine control of the physicochemical properties, which will be exploited in future studies into the prominent self-assembling behavior of such materials.

Original languageEnglish
Pages (from-to)4853-4859
Number of pages7
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Issue number22
Early online date16 Sept 2013
Publication statusPublished - 15 Nov 2013


  • block copolymers
  • peptides
  • synthesis


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