Frontopolar cortical inefficiency may underpin reward and working memory dysfunction in bipolar disorder

Jigar Jogia, Danai Dima, Veena Kumari, Sophia Frangou

Research output: Contribution to journalArticlepeer-review


Objectives. Emotional dysregulation in bipolar disorder is thought to arise from dysfunction within prefrontal cortical regions involved in cognitive control coupled with increased or aberrant activation within regions engaged in emotional processing. The aim of this study was to determine the common and distinct patterns of functional brain abnormalities during reward and working memory processing in patients with bipolar disorder. Methods. Participants were 36 euthymic bipolar disorder patients and 37 healthy comparison subjects matched for age, sex and IQ. Functional magnetic resonance imaging (fMRI) was conducted during the Iowa Gambling Task (IGT) and the n-back working memory task. Results. During both tasks, patients with bipolar disorder demonstrated a pattern of inefficient engagement within the ventral frontopolar prefrontal cortex with evidence of segregation along the medial-lateral dimension for reward and working memory processing, respectively. Moreover, patients also showed greater activation in the anterior cingulate cortex during the Iowa Gambling Task and in the insula during the n-back task. Conclusions. Our data implicate ventral frontopolar dysfunction as a core abnormality underpinning bipolar disorder and confirm that overactivation in regions involved in emotional arousal is present even in tasks that do not typically engage emotional systems.
Original languageEnglish
Pages (from-to)605-615
Number of pages11
JournalWorld Journal of Biological Psychiatry
Issue number8
Publication statusPublished - Dec 2012


  • reward
  • bipolar disorder
  • magnetic resonance imaging
  • prefrontal cortex
  • memory


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