Future therapies

Clifford J. Bailey*, Caroline Day

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


New and improved therapies are required for type 1and type 2 diabetic patients to assist the return of glucose homeostasis to as near normal as possible. More intensive use of existing therapies is proving beneficial, while potential new agents are progressing in development. These include agents to improve and partially mimic insulin action, such as peroxisome proliferator-activated receptor-gamma (PPARγ) agonists, stimulants of intracellular insulin signalling intermediates, and inhibitors of substances that deactivate insulin receptor tyrosine kinase activity. Novel agents to enhance nutrient-stimulated insulin release and promote the replication and neogenesis of b-cells are emerging, along with new agents to combat obesity and dyslipidaemia. Gene therapy approaches to replace defective or destroyed b-cells are feasible future options for both type 1 and type 2 diabetes.

Original languageEnglish
Pages (from-to)s82-s88
JournalCurrent Medical Research and Opinion
Issue numberSUPPL. 1
Publication statusPublished - 1 Dec 2002


  • Antidiabetic drugs
  • Antiobesity agents
  • Future therapies
  • Gene therapy
  • Insulin action enhancers
  • Insulin delivery
  • Insulin releasers
  • Minerals
  • PPAR-gamma agonists-Vanadium
  • Vitamins


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