Human corneal stromal lamellar organisation: A polarised light study in pseudophakic eyes

G. P. Misson*, B. H. Timmerman, P. J. Bryanston-Cross

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A novel qualitative method is presented for determining the macroscopic distribution of collagen lamellae within the central human cornea in vivo. A modified digital photo slit-lamp camera adapted for use with circular polarised light is used. 19 eyes of 10 pseudophakic subjects (with prosthetic intraocular lens implants) are involved in the experiment. Confocal elliptic/hyperbolic populations of collagen fibrils in central and intermediate corneal zones are identified in all eyes with a superotemporal-inferonasal preferred orientation. Approximate mirror symmetry is found to exist between pairs of eyes. The results demonstrate capability for detail not previously reported. The identified distribution of central collagen is consistent with the reported birefringent properties of the central cornea and is compatible with X-ray scatter findings.

Original languageEnglish
Pages (from-to)625-637
Number of pages13
JournalJournal of Modern Optics
Volume55
Issue number4-5
DOIs
Publication statusPublished - 1 Feb 2008

Keywords

  • Circular polarised light
  • Collagen
  • Cornea
  • Ophthalmology
  • Stroma
  • Structure

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