Ictal-interictal continuum: A proposed treatment algorithm

Valia Rodríguez, Meghan F Rodden, Suzette M LaRoche

Research output: Contribution to journalArticlepeer-review


The ictal-interictal continuum (IIC) is characterized by periodic and/or rhythmic EEG patterns that occur with relative high frequency in critically ill patients. Several studies have reported that some patterns seen within the continuum are independently associated with poor outcome. However there is no consensus regarding when to treat them or how aggressive treatment should be. In this review we examine peer-reviewed original scientific articles, guidelines and reviews indexed in PubMed and summarize current knowledge related to the ictal-interictal continuum. A treatment algorithm to guide management of critically ill patients with EEG patterns that fall along the IIC is proposed. The algorithm-based on best current practice in adults-takes into account associated clinical events, risk factors for developing seizures, response to medication trials and biomarkers of neuronal injury.

Original languageEnglish
Pages (from-to)2056-64
Number of pages9
JournalClinical Neurophysiology
Issue number4
Early online date11 Feb 2016
Publication statusPublished - Apr 2016

Bibliographical note

Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd.


  • Adult
  • Aged
  • Algorithms
  • Critical Illness
  • Electroencephalography
  • Female
  • Humans
  • Intensive Care Units
  • Male
  • Risk Factors
  • Seizures
  • Treatment Outcome
  • Case Reports
  • Journal Article
  • Review


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