Identification and validation of the mode of action of the chalcone anti-mycobacterial compounds

Keyphrases

• Antimycobacterial Activity 100%
• Mode of Action 100%
• Chalcone 100%
• InhA 100%
• Mycolic Acid 75%
• Dose Effect 50%
• Methyl Ester 50%
• Fatty Acid Methyl Ester Analysis 50%
• IC50 25%
• Ligand Binding 25%
• Tryptophan 25%
• Overexpressing 25%
• Safety Profile 25%
• Direct Binding 25%
• Medicinal Chemistry 25%
• Molecular Docking 25%
• Cellular Targets 25%
• Thin Layer Chromatography 25%
• M. Bovis BCG 25%
• Growth Inhibition Assay 25%
• Fatty Acid Methyl Esters 25%
• Good Safety 25%
• Mycolic Acid Biosynthesis 25%
• Mycobacterium Bovis BCG 25%
• Hit Compound 25%
• Direct Inhibitors 25%
• TB Chemotherapy 25%
• Intrinsic Tryptophan Fluorescence 25%
• Anti-TB Drug Development 25%
• FAS-II 25%
• Fluorescence Binding Assay 25%
• TB Drugs 25%
• Overexpressing Strains 25%
• Anti-TB 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Mycolic Acid 100%
• Antimycobacterial 100%
• Chalcone 100%
• Fatty Acid Ester 75%
• Tryptophan 50%
• Antimycobacterial Agent 50%
• Mycobacterium Bovis BCG 50%
• IC50 25%
• Drug Development 25%
• Chemotherapy 25%
• Pharmaceutical Chemistry 25%