IMI - Clinical Myopia Control Trials and Instrumentation Report

James S Wolffsohn; Pete S Kollbaum; David A Berntsen; David A Atchison; Alexandra Benavente; Arthur Bradley; Hetal Buckhurst; Michael Collins; Takashi Fujikado; Takahiro Hiraoka; Masakazu Hirota; Debbie Jones; Nicola S Logan; Linda Lundström; Hidemasa Torii; Scott A Read; Kovin Naidoo

doi:10.1167/iovs.18-25955

IMI - Clinical Myopia Control Trials and Instrumentation Report

James S Wolffsohn, Pete S Kollbaum, David A Berntsen, David A Atchison, Alexandra Benavente, Arthur Bradley, Hetal Buckhurst, Michael Collins, Takashi Fujikado, Takahiro Hiraoka, Masakazu Hirota, Debbie Jones, Nicola S Logan, Linda Lundström, Hidemasa Torii, Scott A Read, Kovin Naidoo

Research output: Contribution to journal › Review article › peer-review

Abstract

The evidence-basis based on existing myopia control trials along with the supporting academic literature were reviewed; this informed recommendations on the outcomes suggested from clinical trials aimed at slowing myopia progression to show the effectiveness of treatments and the impact on patients. These outcomes were classified as primary (refractive error and/or axial length), secondary (patient reported outcomes and treatment compliance), and exploratory (peripheral refraction, accommodative changes, ocular alignment, pupil size, outdoor activity/lighting levels, anterior and posterior segment imaging, and tissue biomechanics). The currently available instrumentation, which the literature has shown to best achieve the primary and secondary outcomes, was reviewed and critiqued. Issues relating to study design and patient selection were also identified. These findings and consensus from the International Myopia Institute members led to final recommendations to inform future instrumentation development and to guide clinical trial protocols.

Original language	English
Pages (from-to)	M132-M160
Journal	Investigative Ophthalmology and Visual Science
Volume	60
Issue number	3
DOIs	https://doi.org/10.1167/iovs.18-25955
Publication status	Published - 28 Feb 2019

Bibliographical note

Keywords

Clinical trial guidelines
Instrumentation
Myopia control
Myopia progression
Recommendations
Internationality
Humans
Randomized Controlled Trials as Topic/standards
Evidence-Based Medicine
Myopia/diagnosis
Disease Progression

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IMI – Clinical Myopia Control Trials and Instrumentation Report
Copyright 2019 The Authors. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
Final published version, 1.25 MBLicence: CC BY-NC-ND 3.0

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Wolffsohn, J. S., Kollbaum, P. S., Berntsen, D. A., Atchison, D. A., Benavente, A., Bradley, A., Buckhurst, H., Collins, M., Fujikado, T., Hiraoka, T., Hirota, M., Jones, D., Logan, N. S., Lundström, L., Torii, H., Read, S. A., & Naidoo, K. (2019). IMI - Clinical Myopia Control Trials and Instrumentation Report. Investigative Ophthalmology and Visual Science, 60(3), M132-M160. https://doi.org/10.1167/iovs.18-25955

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Wolffsohn, JS, Kollbaum, PS, Berntsen, DA, Atchison, DA, Benavente, A, Bradley, A, Buckhurst, H, Collins, M, Fujikado, T, Hiraoka, T, Hirota, M, Jones, D, Logan, NS, Lundström, L, Torii, H, Read, SA & Naidoo, K 2019, 'IMI - Clinical Myopia Control Trials and Instrumentation Report', Investigative Ophthalmology and Visual Science, vol. 60, no. 3, pp. M132-M160. https://doi.org/10.1167/iovs.18-25955

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AU - Hiraoka, Takahiro

AU - Hirota, Masakazu

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AU - Logan, Nicola S

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IMI - Clinical Myopia Control Trials and Instrumentation Report

Abstract

Bibliographical note

Keywords

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