Impact of mechanical stretch on the cell behaviors of bone and surrounding tissues

Hye-Sun Yu, Jung-Ju Kim, Hae-Won Kim, Mark P Lewis, Ivan Wall

Research output: Contribution to journalReview articlepeer-review


Mechanical loading is recognized to play an important role in regulating the behaviors of cells in bone and surrounding tissues in vivo. Many in vitro studies have been conducted to determine the effects of mechanical loading on individual cell types of the tissues. In this review, we focus specifically on the use of the Flexercell system as a tool for studying cellular responses to mechanical stretch. We assess the literature describing the impact of mechanical stretch on different cell types from bone, muscle, tendon, ligament, and cartilage, describing individual cell phenotype responses. In addition, we review evidence regarding the mechanotransduction pathways that are activated to potentiate these phenotype responses in different cell populations.

Original languageEnglish
JournalJournal of Tissue Engineering
Publication statusPublished - 16 Mar 2016

Bibliographical note

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