In vitro bioactivity of titanium-doped bioglass

Imran M. Asif; Richard M. Shelton; Paul R. Cooper; Owen Addison; Richard A. Martin

doi:10.1007/s10856-014-5230-4

In vitro bioactivity of titanium-doped bioglass

Imran M. Asif, Richard M. Shelton, Paul R. Cooper, Owen Addison, Richard A. Martin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Previous studies have suggested that incorporating relatively small quantities of titanium dioxide into bioactive glasses may result in an increase in bioactivity and hydroxyapatite formation. The present work therefore investigated the in vitro bioactivity of a titanium doped bioglass and compared the results with 45S5 bioglass. Apatite formation was evaluated for bioglass and Ti-bioglass in the presence and absence of foetal calf serum. Scanning electron microscopy (SEM) images were used to evaluate the surface development and energy dispersive X-ray measurements provided information on the elemental ratios. X-ray diffraction spectra confirmed the presence of apatite formation. Cell viability was assessed for bone marrow stromal cells under direct and indirect contact conditions and cell adhesion was assessed using SEM.

Original language	English
Pages (from-to)	1865-1873
Number of pages	9
Journal	Journal of Materials Science : Materials in Medicine
Volume	25
Issue number	8
Early online date	7 May 2014
DOIs	https://doi.org/10.1007/s10856-014-5230-4
Publication status	Published - Aug 2014

Bibliographical note

The final publication is available at Springer via http://dx.doi.org/10.1007/s10856-014-5230-4

Access to Document

10.1007/s10856-014-5230-4

In vitro bioactivity of titanium-doped bioglass
The final publication is available at Springer via http://dx.doi.org/10.1007/s10856-014-5230-4
Accepted author manuscript, 4.48 MB

http://link.springer.com/article/10.1007%2Fs10856-014-5230-4

Cite this

@article{45368918c3c4411a8004fc79d2c3c421,

title = "In vitro bioactivity of titanium-doped bioglass",

abstract = "Previous studies have suggested that incorporating relatively small quantities of titanium dioxide into bioactive glasses may result in an increase in bioactivity and hydroxyapatite formation. The present work therefore investigated the in vitro bioactivity of a titanium doped bioglass and compared the results with 45S5 bioglass. Apatite formation was evaluated for bioglass and Ti-bioglass in the presence and absence of foetal calf serum. Scanning electron microscopy (SEM) images were used to evaluate the surface development and energy dispersive X-ray measurements provided information on the elemental ratios. X-ray diffraction spectra confirmed the presence of apatite formation. Cell viability was assessed for bone marrow stromal cells under direct and indirect contact conditions and cell adhesion was assessed using SEM.",

author = "Asif, {Imran M.} and Shelton, {Richard M.} and Cooper, {Paul R.} and Owen Addison and Martin, {Richard A.}",

note = "The final publication is available at Springer via http://dx.doi.org/10.1007/s10856-014-5230-4",

year = "2014",

month = aug,

doi = "10.1007/s10856-014-5230-4",

language = "English",

volume = "25",

pages = "1865--1873",

journal = "Journal of Materials Science : Materials in Medicine",

issn = "0957-4530",

publisher = "Springer",

number = "8",

}

TY - JOUR

T1 - In vitro bioactivity of titanium-doped bioglass

AU - Asif, Imran M.

AU - Shelton, Richard M.

AU - Cooper, Paul R.

AU - Addison, Owen

AU - Martin, Richard A.

N1 - The final publication is available at Springer via http://dx.doi.org/10.1007/s10856-014-5230-4

PY - 2014/8

Y1 - 2014/8

N2 - Previous studies have suggested that incorporating relatively small quantities of titanium dioxide into bioactive glasses may result in an increase in bioactivity and hydroxyapatite formation. The present work therefore investigated the in vitro bioactivity of a titanium doped bioglass and compared the results with 45S5 bioglass. Apatite formation was evaluated for bioglass and Ti-bioglass in the presence and absence of foetal calf serum. Scanning electron microscopy (SEM) images were used to evaluate the surface development and energy dispersive X-ray measurements provided information on the elemental ratios. X-ray diffraction spectra confirmed the presence of apatite formation. Cell viability was assessed for bone marrow stromal cells under direct and indirect contact conditions and cell adhesion was assessed using SEM.

AB - Previous studies have suggested that incorporating relatively small quantities of titanium dioxide into bioactive glasses may result in an increase in bioactivity and hydroxyapatite formation. The present work therefore investigated the in vitro bioactivity of a titanium doped bioglass and compared the results with 45S5 bioglass. Apatite formation was evaluated for bioglass and Ti-bioglass in the presence and absence of foetal calf serum. Scanning electron microscopy (SEM) images were used to evaluate the surface development and energy dispersive X-ray measurements provided information on the elemental ratios. X-ray diffraction spectra confirmed the presence of apatite formation. Cell viability was assessed for bone marrow stromal cells under direct and indirect contact conditions and cell adhesion was assessed using SEM.

UR - http://www.scopus.com/inward/record.url?scp=84904413312&partnerID=8YFLogxK

U2 - 10.1007/s10856-014-5230-4

DO - 10.1007/s10856-014-5230-4

M3 - Article

AN - SCOPUS:84904413312

SN - 0957-4530

VL - 25

SP - 1865

EP - 1873

JO - Journal of Materials Science : Materials in Medicine

JF - Journal of Materials Science : Materials in Medicine

IS - 8

ER -

In vitro bioactivity of titanium-doped bioglass

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this