In vitro bioactivity of titanium-doped bioglass

Imran M. Asif, Richard M. Shelton, Paul R. Cooper, Owen Addison, Richard A. Martin*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review


    Previous studies have suggested that incorporating relatively small quantities of titanium dioxide into bioactive glasses may result in an increase in bioactivity and hydroxyapatite formation. The present work therefore investigated the in vitro bioactivity of a titanium doped bioglass and compared the results with 45S5 bioglass. Apatite formation was evaluated for bioglass and Ti-bioglass in the presence and absence of foetal calf serum. Scanning electron microscopy (SEM) images were used to evaluate the surface development and energy dispersive X-ray measurements provided information on the elemental ratios. X-ray diffraction spectra confirmed the presence of apatite formation. Cell viability was assessed for bone marrow stromal cells under direct and indirect contact conditions and cell adhesion was assessed using SEM.

    Original languageEnglish
    Pages (from-to)1865-1873
    Number of pages9
    JournalJournal of Materials Science : Materials in Medicine
    Issue number8
    Early online date7 May 2014
    Publication statusPublished - Aug 2014

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