In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions

Jeremy Chung Bo Chiang, Maitreyee Roy, Juno Kim, Maria Markoulli, Arun V. Krishnan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


In-vivo corneal confocal microscopy is a powerful imaging technique which provides clinicians and researcher with the capabilities to observe microstructures at the ocular surfaces in significant detail. In this Mini Review, the optics and image analysis methods with the use of corneal confocal microscopy are discussed. While novel insights of neuroanatomy and biology of the eyes, particularly the ocular surface, have been provided by corneal confocal microscopy, some debatable elements observed using this technique remain and these are explored in this Mini Review. Potential improvements in imaging methodology and instrumentation are also suggested.
Original languageEnglish
Article number652
Number of pages7
JournalCommunications Biology
Issue number1
Early online date19 Jun 2023
Publication statusPublished - 19 Jun 2023

Bibliographical note

Copyright © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License.


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