Interactions between high-intensity light and optical refocus in the drive for hyperopia control

Sayantan Biswas; Joanna Marie Fianza Busoy; Veluchamy A. Barathi; Leopold Schmetterer; Dan Milea; Biten K. Kathrani; Noel A. Brennan; Raymond P. Najjar

Interactions between high-intensity light and optical refocus in the drive for hyperopia control

Sayantan Biswas, Joanna Marie Fianza Busoy, Veluchamy A. Barathi, Leopold Schmetterer, Dan Milea, Biten K. Kathrani, Noel A. Brennan, Raymond P. Najjar

Optometry

Research output: Chapter in Book/Published conference output › Conference publication

Abstract

Purpose : To evaluate the synergetic impact of high-intensity light (HL) and optical refocus (RF) on lens induced hyperopia (LIH) in a chicken model.

Methods : One-day-old chicks (n=130) were assigned to 10 groups of 13 chicks each. Chicks were housed for 8 days in a 12/12h light-dark cycle (150 lux). In all groups, hyperopia was induced randomly in one eye from day 1 post-hatching (D1) until D8 using +10D lenses. The fellow eyes acted as uncovered control. Nine groups were exposed daily to continuous 2 hours (h), 4h or 6h of either HL (15,000 lux); RF (removal of +10D lens); or both (HL+RF). One control group remained without HL or RF interventions. Ocular axial length (AL), refractive error and choroidal thickness (CT) were measured on D1, D4 and D8 using ultrasonography, infra-red refractometry and optical coherence tomography. Outcome measures are expressed as inter-ocular difference (IOD=experimental-control eye) ± SEM and compared between groups and intervention durations using a 2-way ANOVA.

Results : By D8, LIH led to a significant decrease in AL (-0.42±0.03 mm), increased hyperopic refraction (+3.48±0.32 D) and choroidal thickening (+85.8±35.2 µm) in the control group (all, P
Conclusions : In eyes developing LIH, daily exposures to HL promotes axial shortening and hyperopia in a duration-dependent manner, whereas, RF promotes emmetropization and slows the development of LIH. Exposure to 6h of HL can modulate the drive of RF potentially through changes involving CT.

Original language	English
Title of host publication	ARVO Annual Meeting Abstract
Volume	63
Publication status	Published - Jun 2022

Publication series

Name	Investigative Ophthalmology & Visual Science
Volume	63
ISSN (Electronic)	1552-5783

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Biswas, S., Busoy, J. M. F., Barathi, V. A., Schmetterer, L., Milea, D., Kathrani, B. K., Brennan, N. A., & Najjar, R. P. (2022). Interactions between high-intensity light and optical refocus in the drive for hyperopia control. In ARVO Annual Meeting Abstract (Vol. 63). Article 2782562 (Investigative Ophthalmology & Visual Science; Vol. 63). https://iovs.arvojournals.org/article.aspx?articleid=2782562

@inproceedings{aff9502b6cf4429c9a2e173a0cf32bd6,

title = "Interactions between high-intensity light and optical refocus in the drive for hyperopia control",

abstract = "Purpose : To evaluate the synergetic impact of high-intensity light (HL) and optical refocus (RF) on lens induced hyperopia (LIH) in a chicken model.Methods : One-day-old chicks (n=130) were assigned to 10 groups of 13 chicks each. Chicks were housed for 8 days in a 12/12h light-dark cycle (150 lux). In all groups, hyperopia was induced randomly in one eye from day 1 post-hatching (D1) until D8 using +10D lenses. The fellow eyes acted as uncovered control. Nine groups were exposed daily to continuous 2 hours (h), 4h or 6h of either HL (15,000 lux); RF (removal of +10D lens); or both (HL+RF). One control group remained without HL or RF interventions. Ocular axial length (AL), refractive error and choroidal thickness (CT) were measured on D1, D4 and D8 using ultrasonography, infra-red refractometry and optical coherence tomography. Outcome measures are expressed as inter-ocular difference (IOD=experimental-control eye) ± SEM and compared between groups and intervention durations using a 2-way ANOVA.Results : By D8, LIH led to a significant decrease in AL (-0.42±0.03 mm), increased hyperopic refraction (+3.48±0.32 D) and choroidal thickening (+85.8±35.2 µm) in the control group (all, PConclusions : In eyes developing LIH, daily exposures to HL promotes axial shortening and hyperopia in a duration-dependent manner, whereas, RF promotes emmetropization and slows the development of LIH. Exposure to 6h of HL can modulate the drive of RF potentially through changes involving CT.",

author = "Sayantan Biswas and Busoy, {Joanna Marie Fianza} and Barathi, {Veluchamy A.} and Leopold Schmetterer and Dan Milea and Kathrani, {Biten K.} and Brennan, {Noel A.} and Najjar, {Raymond P.}",

note = "This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.",

year = "2022",

month = jun,

language = "English",

volume = "63",

series = "Investigative Ophthalmology & Visual Science",

booktitle = "ARVO Annual Meeting Abstract",

}

Biswas, S, Busoy, JMF, Barathi, VA, Schmetterer, L, Milea, D, Kathrani, BK, Brennan, NA & Najjar, RP 2022, Interactions between high-intensity light and optical refocus in the drive for hyperopia control. in ARVO Annual Meeting Abstract. vol. 63, 2782562, Investigative Ophthalmology & Visual Science, vol. 63. <https://iovs.arvojournals.org/article.aspx?articleid=2782562>

Interactions between high-intensity light and optical refocus in the drive for hyperopia control. / Biswas, Sayantan; Busoy, Joanna Marie Fianza; Barathi, Veluchamy A. et al.
ARVO Annual Meeting Abstract. Vol. 63 2022. 2782562 (Investigative Ophthalmology & Visual Science; Vol. 63).

Research output: Chapter in Book/Published conference output › Conference publication

TY - GEN

T1 - Interactions between high-intensity light and optical refocus in the drive for hyperopia control

AU - Biswas, Sayantan

AU - Busoy, Joanna Marie Fianza

AU - Barathi, Veluchamy A.

AU - Schmetterer, Leopold

AU - Milea, Dan

AU - Kathrani, Biten K.

AU - Brennan, Noel A.

AU - Najjar, Raymond P.

N1 - This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

PY - 2022/6

Y1 - 2022/6

N2 - Purpose : To evaluate the synergetic impact of high-intensity light (HL) and optical refocus (RF) on lens induced hyperopia (LIH) in a chicken model.Methods : One-day-old chicks (n=130) were assigned to 10 groups of 13 chicks each. Chicks were housed for 8 days in a 12/12h light-dark cycle (150 lux). In all groups, hyperopia was induced randomly in one eye from day 1 post-hatching (D1) until D8 using +10D lenses. The fellow eyes acted as uncovered control. Nine groups were exposed daily to continuous 2 hours (h), 4h or 6h of either HL (15,000 lux); RF (removal of +10D lens); or both (HL+RF). One control group remained without HL or RF interventions. Ocular axial length (AL), refractive error and choroidal thickness (CT) were measured on D1, D4 and D8 using ultrasonography, infra-red refractometry and optical coherence tomography. Outcome measures are expressed as inter-ocular difference (IOD=experimental-control eye) ± SEM and compared between groups and intervention durations using a 2-way ANOVA.Results : By D8, LIH led to a significant decrease in AL (-0.42±0.03 mm), increased hyperopic refraction (+3.48±0.32 D) and choroidal thickening (+85.8±35.2 µm) in the control group (all, PConclusions : In eyes developing LIH, daily exposures to HL promotes axial shortening and hyperopia in a duration-dependent manner, whereas, RF promotes emmetropization and slows the development of LIH. Exposure to 6h of HL can modulate the drive of RF potentially through changes involving CT.

AB - Purpose : To evaluate the synergetic impact of high-intensity light (HL) and optical refocus (RF) on lens induced hyperopia (LIH) in a chicken model.Methods : One-day-old chicks (n=130) were assigned to 10 groups of 13 chicks each. Chicks were housed for 8 days in a 12/12h light-dark cycle (150 lux). In all groups, hyperopia was induced randomly in one eye from day 1 post-hatching (D1) until D8 using +10D lenses. The fellow eyes acted as uncovered control. Nine groups were exposed daily to continuous 2 hours (h), 4h or 6h of either HL (15,000 lux); RF (removal of +10D lens); or both (HL+RF). One control group remained without HL or RF interventions. Ocular axial length (AL), refractive error and choroidal thickness (CT) were measured on D1, D4 and D8 using ultrasonography, infra-red refractometry and optical coherence tomography. Outcome measures are expressed as inter-ocular difference (IOD=experimental-control eye) ± SEM and compared between groups and intervention durations using a 2-way ANOVA.Results : By D8, LIH led to a significant decrease in AL (-0.42±0.03 mm), increased hyperopic refraction (+3.48±0.32 D) and choroidal thickening (+85.8±35.2 µm) in the control group (all, PConclusions : In eyes developing LIH, daily exposures to HL promotes axial shortening and hyperopia in a duration-dependent manner, whereas, RF promotes emmetropization and slows the development of LIH. Exposure to 6h of HL can modulate the drive of RF potentially through changes involving CT.

UR - https://iovs.arvojournals.org/article.aspx?articleid=2782562

M3 - Conference publication

VL - 63

T3 - Investigative Ophthalmology & Visual Science

BT - ARVO Annual Meeting Abstract

ER -

Interactions between high-intensity light and optical refocus in the drive for hyperopia control

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