Laser Speckle Contrast Imaging for Intraoperative Monitoring of Cerebral Blood Flow

D. D. Stavtsev*, A. N. Konovalov, E. V. Blinova, G. A. Piavchenko, G. E. Golodnev, S. D. Zalogin, A. V. Gorina, K. N. Lapin, S. A. Vagner, F. V. Grebenev, I. V. Meglinski, A. Yu Gerasimenko, D. V. Telyshev, S. L. Kuznetsov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Abstract: Intraoperative monitoring of cerebral blood flow provides an important information required for clinicians to select optimal tactics during the neurosurgery procedures, including clipping cerebral vessel aneurysms, bypass, and arteriovenous malformation surgery. Presently, robust cost-effective non-invasive optical imaging techniques suitable to assess cerebral blood flow in the operating room do not exist. In current study we report a development of prototype of the Laser Speckle Contrast Imaging (LSCI) system as a complementary tool for non-invasive real-time visualization and quantitative assessment of cerebral blood flow during neurovascular surgery. The LSCI is based on the scattering of coherent laser light within dynamic turbid medium, such as biological tissues, including brain. The speckle patterns appeared due to interference of partial components of the dynamically scattered light are recorded by digital camera. To observe blood flow in large and small vessels as well as in the microcirculatory bed of the cerebral cortex the recorded images are quantitatively analyzed utilizing low-order statistical moment, known as imaging contrast or enhancement of visibility. The purpose of current pilot study is to assess general feasibility of the LSCI approach in terms technical abilities of image acquisition, its quality evaluation and further implication to day-to-day clinical practice.

Original languageEnglish
Pages (from-to)S229-S233
JournalBulletin of the Russian Academy of Sciences: Physics
Publication statusPublished - 12 Jan 2023

Bibliographical note

Funding Information:
The study was supported by the Russian Science Foundation (project no. 22-65-00096, https://www.rscf.ruproject/22-65-00096/ ).

Publisher Copyright:
© 2022, Allerton Press, Inc.


  • blood flow visualization
  • brain
  • carotid artery ligating
  • laser speckle contrast imaging


Dive into the research topics of 'Laser Speckle Contrast Imaging for Intraoperative Monitoring of Cerebral Blood Flow'. Together they form a unique fingerprint.

Cite this