Limitations of the isolated GP-STN network

Ian M. Stanford, K.C. Loucif, Clare L. Wilson, D. Cash, M.G. Lacey

Research output: Chapter in Book/Published conference outputChapter


An in vitro mouse slice preparation from control and MPTP-treated mice in which functional reciprocal GP-STN connectivity is maintained, does not produce oscillatory bursting or synchronous activity neuronal activity. Pharmacological interventions that produce bursting activity do so without concomitant neuronal synchrony, or a requirement for glutamate or GABA transmission. Pre-treatment with MPTP did not alter this behaviour. Thus, we have no evidence that the functionally connected, but isolated, GP — STN network can act as a pacemaker for synchronous correlated activity in the basal ganglia and must conclude that other inputs such as those from cortex and/or striatum are required.
Original languageEnglish
Title of host publicationThe Basal Ganglia VIII
EditorsJ.P. Bolam, C.A. Ingham, P.J. Magill
Place of PublicationNew York (US)
Number of pages9
ISBN (Print)9780387280653
Publication statusPublished - 25 Dec 2005
EventBasal Ganglia VIII -
Duration: 25 Dec 200525 Dec 2005

Publication series

NameAdvances in Behavioral Biology


ConferenceBasal Ganglia VIII

Bibliographical note

8th Triennial Meeting of the International-Basal-Ganglia-Society, Crieff, Scotland, 5-9 September 2004


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