Liposomes as models for membrane integrity

Sarah J. Routledge, John A. Linney, Alan D. Goddard

Research output: Contribution to journalReview articlepeer-review


Biological membranes form the boundaries to cells. They are integral to cellular function, retaining the valuable components inside and preventing access of unwanted molecules. Many different classes of molecules demonstrate disruptive properties to the plasma membrane. These include alcohols, detergents and antimicrobial agents. Understanding this disruption and the mechanisms by which it can be mitigated is vital for improved therapeutics as well as enhanced industrial processes where the compounds produced can be toxic to the membrane. This mini-review describes the most common molecules that disrupt cell membranes along with a range of in vitro liposome-based techniques that can be used to monitor and delineate these disruptive processes.
Original languageEnglish
Pages (from-to)919-932
Number of pages14
JournalBiochemical Society Transactions
Issue number3
Early online date13 May 2019
Publication statusPublished - 28 Jun 2019

Bibliographical note

© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society


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